| Title (croatian) | Kirurška patologija |
| Title (english) | Surgical pathology |
| Author | Dora Fučkar Čupić |
| Author's institution | University of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy) |
Scientific / art field,
discipline and subdiscipline | BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology |
| Abstract (croatian) | Kirurška patologija najznačajniji je i vremenski najzahtjevniji dio prakse većine patologa. Ima za cilj dati/isključiti definitivnu dijagnozu bolesti temeljeći se na uzorcima tkiva. Dva su glavna tipa tkivnih uzoraka za patološku analizu: biopsije i kirurške resekcije. Četiri su glavna dijela kirurške patologije koji se koriste u konačnoj dijagnostici tkivnih uzoraka: makroskopski pregled, patohistološki pregled koji se temelji na svjetlosnoj mikroskopiji, imunohistokemija i molekularne/citogenetske analize. Rezultat rada patologa je patohistološko izvješće. Ono sadrži makroskopski i mikroskopski opis lezije, dijagnozu ili diferencijalnu dijagnozu. Postoje situacije kada je potrebno dijagnozu postaviti za vrijeme kirurškog zahvata, dok je pacijent pod anestezijom. Tada se koristi hitna ili intraoperacijska biopsija, na smrznutim tkivnim rezovima. Hitna ili intraoperacijska biopsija je hitno stanje u patologiji koje zahtijeva dobru suradnju između kirurga i patologa te iskusnog i dobro educiranog patologa koji je svjestan mogućnosti, ali i ograničenja hitne biopsije. Resekcijski rubovi su rubovi ili površine koje je napravio kirurg. Udaljenost između tumora i resekcijskog ruba naziva se kirurški rub. Kirurški rubovi izuzetno su važni jer pozitivnost rubova korelira s recidivom bolesti. Definicija pozitivnog kirurškog ruba ovisi o vrsti tumora, njegovoj biologiji i lokalizaciji bolesti. Jedan od najvažnijih ciljeva kirurške patologije je dijagnostika malignih bolesti i procjena proširenosti bolesti, odnosno klasifikacija tumora, prema odrednicama Svjetske zdravstvene organizacije. Patološka klasifikacija (p) malignih bolesti označava se kao pTNM (primarni tumor – T, regionalni limfni čvorovi – N, udaljene metastaze – M). Ona se temelji na podacima dobivenim prije kirurškog liječenja uz modifikaciju proizašlu iz patohistološke analize tkiva. |
| Abstract (english) | The most important part of pathology work is surgical pathology. Its goal is to diagnose or exclude the clinical diagnosis based on tissue samples. Two main types of tissue samples for pathohistologic analyses are biopsies and surgical resections. There are four main parts used in final diagnosis of tissue samples in surgical pathology: macroscopic exam, pathohistologic analysis, immunohistochemistry and molecular/cytogenetic analysis. The result of pathologists’ work is pathohistologic report, which contains macroscopic and microscopic description of a lesion, diagnosis or differential diagnosis. There are situations when diagnosis needs to be established during surgical procedure, while the patient is under anesthesia, so pathologist uses so called intraoperative biopsy or frozen tissue sections. This is an emergency in pathology practice and it requires good cooperation between surgeons and pathologists. The surgical margins are surfaces that were cut by the surgeon. The distance between the tumour and the margin is called surgical margin. Margins are important as an incompletely removed disease process may lead to reccurrence. What defines a positive surgical margin is dependent on the tumour and its biology; definitions of positive margin are dependent on the anatomical site. One of the most important goals of surgical pathology is diagnosis of malignant diseases and assessment of extent of disease, and not less important, tumour classification, defined by World Health Organization. Pathological classification (p) of malignant diseases (or postsurgical pathohistologic classification) is defined as pTNM (T – tumour, N – lymph node, M – distant metastasis). It is based on presurgical clinical data modified by pathohistological data analysis. |
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| Language | croatian |
| Publication type | Scientific paper - Review paper |
| Publication status | Published |
| Peer review | Peer review |
| Publication version | Published version |
| Journal title | Medicina Fluminensis : Medicina Fluminensis |
| Numbering | vol. 52, no. 3, pp. 337-344 |
| p-ISSN | 0025-7729 |
| DOI | https://doi.org/10.21860/52;3_337 |
| URN:NBN | urn:nbn:hr:184:956486 |
| Publication | 2016-09-01 |
| Document URL | http://hrcak.srce.hr/163931 |
| Type of resource | Text |
| Access conditions | Open access |
| Terms of use |  |
| Created on | 2017-04-20 16:15:13 |
