prikaz prve stranice dokumenta Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes
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Scientific paper - Original scientific paper
Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes
Immunology Letters, 248 (2022); 45-55. https://doi.org/10.1016/j.imlet.2022.06.001
Gašparini, Dora; Kavazović, Inga; Barković, Igor; Maričić, Vitomir; Ivaniš, Viktor; Samsa, Dijana Travica; Peršić, Viktor; Polić, Bojan; Turk Wensveen, Tamara; Wensveen, Felix M.

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Cite this document

Gašparini, D., Kavazović, I., Barković, I., Maričić, V., Ivaniš, V., Samsa, D. T. ... Wensveen, F. M. (2022). Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes. Immunology Letters, 248., 45-55. doi: 10.1016/j.imlet.2022.06.001

Gašparini, Dora, et al. "Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes." Immunology Letters, vol. 248, 2022, pp. 45-55. https://doi.org/10.1016/j.imlet.2022.06.001

Gašparini, Dora, Inga Kavazović, Igor Barković, Vitomir Maričić, Viktor Ivaniš, Dijana Travica Samsa, Viktor Peršić, Bojan Polić, Tamara Turk Wensveen and Felix M. Wensveen. "Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes." Immunology Letters 248 (2022): 45-55. https://doi.org/10.1016/j.imlet.2022.06.001

Gašparini, D., et al. (2022) 'Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes', Immunology Letters, 248, pp. 45-55. doi: 10.1016/j.imlet.2022.06.001

Gašparini D, Kavazović I, Barković I, Maričić V, Ivaniš V, Samsa DT, and sur.. Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes. Immunology Letters [Internet]. 2022 August [cited 2024 May 09];248:45-55. doi: 10.1016/j.imlet.2022.06.001

D. Gašparini, et al., "Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes", Immunology Letters, vol. 248, pp. 45-55, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:907774. [Accessed: 09 May 2024]

Metadata
Title (english)Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes
AuthorDora Gašparini https://orcid.org/0000-0002-0503-9516
AuthorInga Kavazović
AuthorIgor Barković
AuthorVitomir Maričić
AuthorViktor Ivaniš
AuthorDijana Travica Samsa
AuthorViktor Peršić
AuthorBojan Polić
AuthorTamara Turk Wensveen
AuthorFelix M. Wensveen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Exercise has many beneficial effects for our body, but can become detrimental at high intensity, especially for our immune system. Little is known about the underlying mechanism of impaired immune functionality under conditions of intense physical strain. Freedivers, people who dive to high depths on a single breath, perform extreme exercise under anaerobic conditions. In this study, we investigated the impact of freediving on the cytotoxic arm of the immune system. At rest, elite freedivers did not display changes in their immunological profile compared to non-diving controls. In contrast, after a freedive, granzyme B and IL-2 production were reduced, whereas IFNγ and TNF secretion were increased by cytotoxic immune cells. Using in vitro models mimicking freedive conditions, we could show that hypoxia in combination with stress hyperglycemia had a negative impact on Granzyme B secretion, whereas IL-2 production was inhibited by stress hormones. Our findings suggest that in response to extreme exercise, cytotoxic immune cells transiently change their functional profile to limit tissue damage.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunology Letters
Numberingvol. 248, pp. 45-55
p-ISSN0165-2478
DOIhttps://doi.org/10.1016/j.imlet.2022.06.001
URN:NBNurn:nbn:hr:184:907774
Publication2022-08
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Title (english): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Acronym: T-MEMORY
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-CORONA-2020-04-2045
Title (croatian): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Title (english): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Acronym: CORONAWAI
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP-CORONA
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0165247822000827
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-10-26 07:04:59