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Scientific paper - Review paper
Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis
Acta clinica Croatica, 61. (2022), 2; 311-319. https://doi.org/10.20471/acc.2022.61.02.18
Vukelić, Jelena; Dobrila-Dintinjana, Renata; Marijić, Blažen; Maržić, Diana; Braut, Tamara

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Vukelić, J., Dobrila Dintinjana, R., Marijić, B., Maržić, D. & Braut, T. (2022). Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis. Acta clinica Croatica, 61.. (2), 311-319. doi: 10.20471/acc.2022.61.02.18

Vukelić, Jelena, et al. "Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis." Acta clinica Croatica, vol. 61., no. 2, 2022, pp. 311-319. https://doi.org/10.20471/acc.2022.61.02.18

Vukelić, Jelena, Renata Dobrila Dintinjana, Blažen Marijić, Diana Maržić and Tamara Braut. "Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis." Acta clinica Croatica 61., no. 2 (2022): 311-319. https://doi.org/10.20471/acc.2022.61.02.18

Vukelić, J., et al. (2022) 'Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis', Acta clinica Croatica, 61.(2), pp. 311-319. doi: 10.20471/acc.2022.61.02.18

Vukelić J, Dobrila Dintinjana R, Marijić B, Maržić D, Braut T. Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis. Acta clinica Croatica [Internet]. 2022 August 01 [cited 2024 April 25];61.(2):311-319. doi: 10.20471/acc.2022.61.02.18

J. Vukelić, R. Dobrila Dintinjana, B. Marijić, D. Maržić and T. Braut, "Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis", Acta clinica Croatica, vol. 61., no. 2, pp. 311-319, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:943416. [Accessed: 25 April 2024]

Metadata
Title (english)Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis
Title (croatian)Klinički tijek bolesti i ishod liječenja kod bolesnika s malignim tumorima grkljana: retrospektivna petogodišnja analiza
AuthorJelena Vukelić
AuthorRenata Dobrila-Dintinjana
AuthorBlažen Marijić
AuthorDiana Maržić
AuthorTamara Braut
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
The aim was to investigate clinical course of disease in patients with malignant laryngeal tumors with emphasis on various forms of disease recurrence (local recurrence, metastasis to regional lymph nodes, occurrence of second primary tumor). A retrospective research including 78 patients with histopathologically confirmed diagnosis of squamous cell laryngeal carcinoma was conducted. Information on cancer stage, histologic grade, type of treatment and disease recurrence was obtained from medical history. Tissue samples of the patients were submitted to immunohistochemical analysis and assessment of Ki-67 proliferation index expression. The occurrence of second primary tumor was found to be related to the significantly higher Ki-67 proliferation index. The number of patients having not undergone oncologic therapy and remained free from disease recurrence was significantly higher than expected. Treatment outcome depends on patient age, histologic grade, radiotherapy applied, and clinical course of disease. It is necessary to define the predictive factors of various forms of disease recurrence more precisely in order to identify better treatment options for patients with malignant tumors of the larynx.
Abstract (croatian)
Cilj je bio istražiti klinički tijek bolesti kod bolesnika sa zloćudnim tumorima grkljana s osvrtom na razne oblike povrata bolesti (lokalni recidiv, metastaze u regionalne limfne čvorove, pojavnost drugog primarnog tumora). Proveli smo retrospektivno istraživanje na 78 bolesnika s patohistološki potvrđenom dijagnozom planocelularnog karcinoma grkljana. Iz povijesti bolesti dobili smo podatke o stadiju karcinoma, histološkom gradusu, vrsti provedenog liječenja te o povratu bolesti. Na patohistološkim uzorcima tkiva tih bolesnika učinili smo imunohistokemijsku analizu i procjenu ekspresije proliferacijskog čimbenika Ki-67. Pojava drugog primarnog tumora vezana je uz značajno veći proliferacijski indeks Ki-67. Značajno veći je bio udio bolesnika kod kojih nije provedena onkološka terapija, a koji naknadno nisu razvili neki od oblika povrata bolesti. Ishod liječenja ovisi o dobi bolesnika, histološkom gradusu, primijenjenoj radioterapiji i kliničkom tijeku bolesti. Potrebno je preciznije definirati prediktivne čimbenike rizika za razne oblike povrata bolesti kako bismo bolje i kvalitetnije liječili bolesnike s malignim tumorima grkljana.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 61., no. 2, pp. 311-319
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2022.61.02.18
URN:NBNurn:nbn:hr:184:943416
Online first2022-08-01
Document URLhttps://hrcak.srce.hr/285011
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-11-02 12:41:48