prikaz prve stranice dokumenta Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
  Download
PDF 3.74 MB
Scientific paper - Original scientific paper
Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
Journal of Materials Chemistry B, (2022); 1-22. https://doi.org/10.1039/D2TB01818G
Nuez-Martínez, Miquel; Queralt-Martín, María; Muñoz-Juan, Amanda; Aguilella, Vicente M.; Laromaine, Anna; Teixidor, Francesc; Viñas, Clara; Pinto, Catarina G.; Pinheiro, Teresa; Guerreiro, Joana F.; Mendes, Filipa; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Valić, Srećko; Marques, Fernanda More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Nuez Martínez, M., Queralt Martín, M., Muñoz Juan, A., Aguilella, V. M., Laromaine, A., Teixidor, F. ... Marques, F. (2022). Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma. Journal of Materials Chemistry B, 1-22. doi: 10.1039/D2TB01818G

Nuez Martínez, Miquel, et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma." Journal of Materials Chemistry B, 2022, pp. 1-22. https://doi.org/10.1039/D2TB01818G

Nuez Martínez, Miquel, María Queralt Martín, Amanda Muñoz Juan, Vicente M. Aguilella, Anna Laromaine, Francesc Teixidor, Clara Viñas, et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma." Journal of Materials Chemistry B (2022): 1-22. https://doi.org/10.1039/D2TB01818G

Nuez Martínez, M., et al. (2022) 'Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma', Journal of Materials Chemistry B, pp. 1-22. doi: 10.1039/D2TB01818G

Nuez Martínez M, Queralt Martín M, Muñoz Juan A, Aguilella VM, Laromaine A, Teixidor F, and sur.. Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma. Journal of Materials Chemistry B [Internet]. 2022 [cited 2024 June 09];1-22. doi: 10.1039/D2TB01818G

M. Nuez Martínez, et al., "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma", Journal of Materials Chemistry B, pp. 1-22, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:188306. [Accessed: 09 June 2024]

Metadata
Title (english)Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
AuthorMiquel Nuez-Martínez
AuthorMaría Queralt-Martín
AuthorAmanda Muñoz-Juan
AuthorVicente M. Aguilella
AuthorAnna Laromaine
AuthorFrancesc Teixidor
AuthorClara Viñas
AuthorCatarina G. Pinto
AuthorTeresa Pinheiro
AuthorJoana F. Guerreiro
AuthorFilipa Mendes
AuthorCatarina Roma-Rodrigues
AuthorPedro V. Baptista
AuthorAlexandra R. Fernandes
AuthorSrećko Valić
AuthorFernanda Marques
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, and is highly resistant to conventional radiotherapy and chemotherapy. Therefore, the development of multidrug resistance and tumor recurrence are frequent. Given the poor survival with the current treatments, new therapeutic strategies are urgently needed. Radiotherapy (RT) is a common cancer treatment modality for GBM. However, there is still a need to improve RT efficiency, while reducing the severe side effects. Radiosensitizers can enhance the killing effect on tumor cells with less side effects on healthy tissues. Herein, we present our pioneering study on the highly stable and amphiphilic metallacarboranes, ferrabis(dicarbollides) ([o-FESAN] and [8, 80-I2-o-FESAN]), as potential radiosensitizers for GBM radiotherapy. We propose radiation methodologies that utilize secondary radiation emissions from iodine and iron, using ferrabis(dicarbollides) as iodine/iron donors, aiming to achieve a greater therapeutic effect than that of a conventional radiotherapy. As a proof-of-concept, we show that using 2D and 3D models of U87 cells, the cellular viability and survival were reduced using this treatment approach. We also tested for the first time the proton boron fusion reaction (PBFR) with ferrabis(dicarbollides), taking advantage of their high boron (11 B) content. The results from the cellular damage response obtained suggest that proton boron fusion radiation therapy, when combined with boron-rich compounds, is a promising modality to fight against resistant tumors. Although these results are encouraging, more developments are needed to further explore ferrabis(dicarbollides) as radiosensitizers towards a positive impact on the therapeutic strategies for GBM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusAccepted
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Materials Chemistry B
Numberingpp. 1-22
p-ISSN2050-750X
e-ISSN2050-7518
DOIhttps://doi.org/10.1039/D2TB01818G
URN:NBNurn:nbn:hr:184:188306
Publication2022
ProjectNumber: IP-2018-01-3168
Title (croatian): Studija važnosti spinskih međudjelovanja kao osnova za nove pristupe u istraživanju materijala
Acronym: SPES
Leader: Marina Ilakovac-Kveder
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://xlink.rsc.org/?DOI=D2TB01818G
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) icon
Created on2022-12-02 09:38:04