prikaz prve stranice dokumenta Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
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Scientific paper - Original scientific paper
Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
International journal of molecular sciences, 24 (2023); 1903. https://doi.org/10.3390/ijms24031903
Jurič, Andreja; Brčić Karačonji, Irena; Gašić, Uroš; Milojković Opsenica, Dušanka; Prđun, Saša; Bubalo, Dragan; Lušić, Dražen; Vahčić, Nada; Kopjar, Nevenka

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Jurič, A., Brčić Karačonji, I., Gašić, U., Milojković Opsenica, D., Prđun, S., Bubalo, D. ... Kopjar, N. (2023). Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study. International journal of molecular sciences, 24.. doi: 10.3390/ijms24031903

Jurič, Andreja, et al. "Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study." International journal of molecular sciences, vol. 24, 2023. https://doi.org/10.3390/ijms24031903

Jurič, Andreja, Irena Brčić Karačonji, Uroš Gašić, Dušanka Milojković Opsenica, Saša Prđun, Dragan Bubalo, Dražen Lušić, Nada Vahčić and Nevenka Kopjar. "Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study." International journal of molecular sciences 24 (2023). https://doi.org/10.3390/ijms24031903

Jurič, A., et al. (2023) 'Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study', International journal of molecular sciences, 24. doi: 10.3390/ijms24031903

Jurič A, Brčić Karačonji I, Gašić U, Milojković Opsenica D, Prđun S, Bubalo D, and sur.. Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study. International journal of molecular sciences [Internet]. 2023 January 18 [cited 2024 May 05];24. doi: 10.3390/ijms24031903

A. Jurič, et al., "Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study", International journal of molecular sciences, vol. 24, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:710801. [Accessed: 05 May 2024]

Metadata
Title (english)Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
Title (english)Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
AuthorAndreja Jurič
MBZ: 359286
AuthorIrena Brčić Karačonji
MBZ: 236105
AuthorUroš Gašić
AuthorDušanka Milojković Opsenica
AuthorSaša Prđun
MBZ: 334512
AuthorDragan Bubalo
MBZ: 200480
AuthorDražen Lušić
AuthorNada Vahčić
MBZ: 125475
AuthorNevenka Kopjar
MBZ: 195102
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Environmental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Strawberry tree (Arbutus unedo L.) honey (STH) has been used since ancient times as a folk medicine remedy, especially in certain Mediterranean countries. This honey, rich in phenolic content, is well recognized for its antioxidant, anti- inflammatory, and antimicrobial activities, and is used for the treatment of skin lesions as well as gastrointestinal and respiratory disorders. This study investigated whether STH alleviates genome damage in human peripheral blood lymphocytes produced by the cytotoxic drug irinotecan. The phenolic profile of STH was previously estimated by ultra-high-performance liquid chromatography coupled to a linear ion trap–Orbitrap hybrid mass spectrometer. The effects of STH were evaluated at three concentrations (1x, 5x, and 10x), based on the daily consumption of the honey by an adult person. After 2 h of in vitro exposure, standard lymphocyte cultures for the analysis of chromosome aberrations and the cytokinesis-block micronucleus cytome assay were established. Our results demonstrate that STH offered remarkable geno- and cytoprotection when administered with irinotecan. These findings are relevant for drawing preliminary conclusions regarding the in vitro safety of the tested honey. However, further studies are needed with the application of more complex experimental models.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational journal of molecular sciences
Numberingvol. 24, 1903
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24031903
URN:NBNurn:nbn:hr:184:710801
Publication2023-01-18
Document URLhttp://bib.irb.hr/1246441
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-01-25 13:11:06