prikaz prve stranice dokumenta Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
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Scientific paper - Original scientific paper
Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
International Journal of Molecular Sciences, 24 (2023), 3; 2278. https://doi.org/10.3390/ijms24032278
Gulić, Tamara; Laškarin, Gordana; Glavan, Lana; Grubić Kezele, Tanja; Haller, Herman; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Gulić, T., Laškarin, G., Glavan, L., Grubić Kezele, T., Haller, H. & Rukavina, D. (2023). Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24032278

Gulić, Tamara, et al. "Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96." International Journal of Molecular Sciences, vol. 24, no. 3, 2023. https://doi.org/10.3390/ijms24032278

Gulić, Tamara, Gordana Laškarin, Lana Glavan, Tanja Grubić Kezele, Herman Haller and Daniel Rukavina. "Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96." International Journal of Molecular Sciences 24, no. 3 (2023). https://doi.org/10.3390/ijms24032278

Gulić, T., et al. (2023) 'Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24032278

Gulić T, Laškarin G, Glavan L, Grubić Kezele T, Haller H, Rukavina D. Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96. International Journal of Molecular Sciences [Internet]. 2023 January 23 [cited 2024 April 26];24(3). doi: 10.3390/ijms24032278

T. Gulić, G. Laškarin, L. Glavan, T. Grubić Kezele, H. Haller and D. Rukavina, "Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96", International Journal of Molecular Sciences, vol. 24, no. 3, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:412331. [Accessed: 26 April 2024]

Metadata
Title (english)Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
AuthorTamara Gulić
AuthorGordana Laškarin
AuthorLana Glavan
AuthorTanja Grubić Kezele
AuthorHerman Haller
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Heat shock proteins (hsps), in certain circumstances, could shape unique features of decidual dendritic cells (DCs) that play a key role in inducing immunity as well as maintaining tolerance. The aim of the study was to assess the binding of gp96 to Toll-like receptor (TLR) 4 and CD91 receptors on decidual CD1a+ DCs present at the maternal-fetal interface in vitro as well as the influence of CD1a+ DCs maturation status. Immunohistology and immunofluorescence of paraffin-embedded first-trimester decidua tissue sections of normal and pathological (missed abortion MA and blighted ovum BO) pregnancies were performed together with flow cytometry detection of antigens in CD1a+ DCs after gp96 stimulation of decidual mononuclear cells. Gp96 efficiently bound CD91 and TLR4 receptors on decidual CD1a+ DCs in a dose-dependent manner and increased the expression of CD83 and HLA-DR. The highest concentration of gp96 (1000 ng/mL) increased the percentage of Interferon-γ (INF-γ) and IL-15 expressing gp96+ cells. Gp96 binds CD91 and TLR4 on decidual CD1a+ DCs, which causes their maturation and significantly increases INF-γ and IL-15 in the context of Th1 cytokine/chemokine domination, which could support immune response harmful for ongoing pregnancy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 3, 2278
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24032278
URN:NBNurn:nbn:hr:184:412331
Publication2023-01-23
Document URLhttps://www.mdpi.com/1422-0067/24/3/2278
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-25 13:55:41