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Scientific paper - Review paper
The role of metallothionein in breast cancer
Libri Oncologici : Croatian Journal of Oncology, 50 (2022), 2-3; 103-108. https://doi.org/10.20471/LO.2022.50.02-03.16
Bilić-Knežević, Sara; Tokić, Mirisa; Gulić, Tamara; Avirović, Manuela; Grebić, Damir

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bilić Knežević, S., Tokić, M., Gulić, T., Avirović, M. & Grebić, D. (2022). The role of metallothionein in breast cancer. Libri Oncologici : Croatian Journal of Oncology, 50. (2-3), 103-108. doi: 10.20471/LO.2022.50.02-03.16

Bilić Knežević, Sara, et al. "The role of metallothionein in breast cancer." Libri Oncologici : Croatian Journal of Oncology, vol. 50, no. 2-3, 2022, pp. 103-108. https://doi.org/10.20471/LO.2022.50.02-03.16

Bilić Knežević, Sara, Mirisa Tokić, Tamara Gulić, Manuela Avirović and Damir Grebić. "The role of metallothionein in breast cancer." Libri Oncologici : Croatian Journal of Oncology 50, no. 2-3 (2022): 103-108. https://doi.org/10.20471/LO.2022.50.02-03.16

Bilić Knežević, S., et al. (2022) 'The role of metallothionein in breast cancer', Libri Oncologici : Croatian Journal of Oncology, 50(2-3), pp. 103-108. doi: 10.20471/LO.2022.50.02-03.16

Bilić Knežević S, Tokić M, Gulić T, Avirović M, Grebić D. The role of metallothionein in breast cancer. Libri Oncologici : Croatian Journal of Oncology [Internet]. 2022 [cited 2024 December 26];50(2-3):103-108. doi: 10.20471/LO.2022.50.02-03.16

S. Bilić Knežević, M. Tokić, T. Gulić, M. Avirović and D. Grebić, "The role of metallothionein in breast cancer", Libri Oncologici : Croatian Journal of Oncology, vol. 50, no. 2-3, pp. 103-108, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:119237. [Accessed: 26 December 2024]

Metadata
Title (english)The role of metallothionein in breast cancer
Title (croatian)Uloga metalotionina u karcinomu dojke
AuthorSara Bilić-Knežević
AuthorMirisa Tokić
AuthorTamara Gulić
AuthorManuela Avirović
AuthorDamir Grebić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Abstract (english)
Metallothioneins (MTs) are a family of small cysteine-rich proteins involved in many physiological and pathological processes. Genes that encode the four isoforms of metallothioneins (MT1-M4) are located on chromosome 16q13. Strucutures of these four isoforms allow metallothioneins their various biological functions. Many studies have shown that MT plays an important role in carcinogenesis, tumour growth, its progression from local to metastatic disease and may contribute to resistence to chemotherapy and radiotherapy. Due to the fact that breast cancer is one of the leading causes of death in women worldwide it is important to better understand the biology of breast cancer. So, findings of MT could evenutally help as a prognostic tool and could lead to a possible new specific anti-cancer treatment.
Abstract (croatian)
Metalotioneini su skupina proteina bogatih cisteinima koji su uključeni u mnoge fiziološke i patološke procese. Geni koji kodiraju četiri izoforme metalotioneina locirani su na lokusu 16q13. Strukture ovih četiriju izoformi omogućuju metalotioneinima njihove razne biološke funkcije. Mnoge su studije pokazale da metalnotionein ima važnu ulogu u karcinogenezi, rastu tumora, njegovoj progresiji od lokalne prema metastatskoj bolesti te je povezan sa razvojem rezistencije na kemoterapiju i radioterapiju. Rak dojke jedan je od vodećih uzroka smrti u svijetu i važno je bolje razumijeti ulogu metalotioneina u različitim podtipovima karcinoma dojke. Ovakvi podaci mogli bi pomoći kao prognostički alat i voditi pronalasku novog specifičnog liječenja karcinoma.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLibri Oncologici : Croatian Journal of Oncology
Numberingvol. 50, no. 2-3, pp. 103-108
p-ISSN0300-8142
e-ISSN2584-3826
DOIhttps://doi.org/10.20471/LO.2022.50.02-03.16
URN:NBNurn:nbn:hr:184:119237
Publication2022
Document URLhttps://hrcak.srce.hr/288531
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-01-31 10:29:39