prikaz prve stranice dokumenta Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases
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Scientific paper - Original scientific paper
Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases
HemaSphere, 6 (2022), 12; e807. https://doi.org/10.1097/HS9.0000000000000807
Galušić, Davor; Bašić-Kinda, Sandra; Pijuk, Anđela; Milunović, Vibor; Dreta, Barbara; Franjić, Neven; Coha, Božena; Sinčić-Petričević, Jasminka; Gaćina, Petar; Pejsa, Vlatko; Lucijanić, Marko; Aurer, Igor

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Galušić, D., Bašić Kinda, S., Pijuk, A., Milunović, V., Dreta, B., Franjić, N. ... Aurer, I. (2022). Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases. HemaSphere, 6. (12). doi: 10.1097/HS9.0000000000000807

Galušić, Davor, et al. "Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases." HemaSphere, vol. 6, no. 12, 2022. https://doi.org/10.1097/HS9.0000000000000807

Galušić, Davor, Sandra Bašić Kinda, Anđela Pijuk, Vibor Milunović, Barbara Dreta, Neven Franjić, Božena Coha, et al. "Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases." HemaSphere 6, no. 12 (2022). https://doi.org/10.1097/HS9.0000000000000807

Galušić, D., et al. (2022) 'Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases', HemaSphere, 6(12). doi: 10.1097/HS9.0000000000000807

Galušić D, Bašić Kinda S, Pijuk A, Milunović V, Dreta B, Franjić N, and sur.. Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases. HemaSphere [Internet]. 2022 December [cited 2025 January 10];6(12). doi: 10.1097/HS9.0000000000000807

D. Galušić, et al., "Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases", HemaSphere, vol. 6, no. 12, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:450646. [Accessed: 10 January 2025]

Metadata
Title (english)Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases
AuthorDavor Galušić
AuthorSandra Bašić-Kinda
AuthorAnđela Pijuk
AuthorVibor Milunović
AuthorBarbara Dreta
AuthorNeven Franjić
AuthorBožena Coha
AuthorJasminka Sinčić-Petričević
AuthorPetar Gaćina
AuthorVlatko Pejsa
AuthorMarko Lucijanić
AuthorIgor Aurer
Author's institution(Clinical Hospital Center Rijeka)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (croatian)
Obinutuzumab (G) has become part of front-line treatment of follicular lymphoma (FL) based on results of a large randomized study. Data on patients treated outside of clinical trials are lacking. We have retrospectively investigated efficacy and safety of G-based immunochemotherapy regimens in 114 patients treated in a real-life setting during a period of 2 years, largely coinciding with the COVID-19 pandemic. The response rate was 93.8%; 18-months overall (OS) and progression-free survival (PFS) were 88% and 84%, respectively. Patients treated with G-cyclophosphamide, vincristine and glucocorticoid + doxorubicine (CHOP) had statistically significantly superior OS and PFS compared to patients treated with G-bendamustine (G-B) (P = 0.002 and P = 0.006, respectively) due to an increase in lethal infections, most notably COVID-19, in the latter group. A total of 12 patients died during follow-up; 9 of 61 treated with G-B, 1 of 49 treated with G-CHOP and 2 of 4 treated with G-cyclophosphamide, vincristine and glucocorticoid (CVP). SARS-CoV-2 infection was diagnosed in 20 (17.5%) patients. All of the 7 treated with G-CHOP recovered, while 4 of 12 treated with G-B died. Immunoglobulin levels and severity of neutropenia were similar between the groups. In multivariate analysis, G-B in comparison to G-CHOP was an independent prognostic factor (P = 0.044, hazard ratio = 9.81) after adjustment for age, sex and Follicular Lymphoma International Prognostic Index (FLIPI). Based on our experience G has excellent antilymphoma activity in patients receiving front-line treatment for FL in real-life setting, but during the COVID-19 pandemic, it should be preferentially combined with CHOP, at least in patients younger than 65.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleHemaSphere
Numberingvol. 6, no. 12, e807
e-ISSN2572-9241
DOIhttps://doi.org/10.1097/HS9.0000000000000807
URN:NBNurn:nbn:hr:184:450646
Publication2022-12
Document URLhttps://journals.lww.com/10.1097/HS9.0000000000000807
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-02-01 08:14:04