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Scientific paper - Review paper
Comprehensive Insight into Lichen Planus Immunopathogenesis
International Journal of Molecular Sciences, 24 (2023), 3; 3038. https://doi.org/10.3390/ijms24033038
Vičić, Marijana; Hlača, Nika; Kaštelan, Marija; Brajac, Ines; Sotošek, Vlatka; Prpić Massari, Larisa

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Vičić, M., Hlača, N., Kaštelan, M., Brajac, I., Sotošek, V. & Prpić Massari, L. (2023). Comprehensive Insight into Lichen Planus Immunopathogenesis. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24033038

Vičić, Marijana, et al. "Comprehensive Insight into Lichen Planus Immunopathogenesis." International Journal of Molecular Sciences, vol. 24, no. 3, 2023. https://doi.org/10.3390/ijms24033038

Vičić, Marijana, Nika Hlača, Marija Kaštelan, Ines Brajac, Vlatka Sotošek and Larisa Prpić Massari. "Comprehensive Insight into Lichen Planus Immunopathogenesis." International Journal of Molecular Sciences 24, no. 3 (2023). https://doi.org/10.3390/ijms24033038

Vičić, M., et al. (2023) 'Comprehensive Insight into Lichen Planus Immunopathogenesis', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24033038

Vičić M, Hlača N, Kaštelan M, Brajac I, Sotošek V, Prpić Massari L. Comprehensive Insight into Lichen Planus Immunopathogenesis. International Journal of Molecular Sciences [Internet]. 2023 February 03 [cited 2024 December 28];24(3). doi: 10.3390/ijms24033038

M. Vičić, N. Hlača, M. Kaštelan, I. Brajac, V. Sotošek and L. Prpić Massari, "Comprehensive Insight into Lichen Planus Immunopathogenesis", International Journal of Molecular Sciences, vol. 24, no. 3, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:490729. [Accessed: 28 December 2024]

Metadata
Title (english)Comprehensive Insight into Lichen Planus Immunopathogenesis
AuthorMarijana Vičić
AuthorNika Hlača
AuthorMarija Kaštelan
AuthorInes Brajac
AuthorVlatka Sotošek
AuthorLarisa Prpić Massari
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Lichen planus is a chronic disease affecting the skin, appendages, and mucous membranes. A cutaneous lichen planus is a rare disease occurring in less than 1% of the general population, while oral illness is up to five times more prevalent; still, both forms equally impair the patient’s quality of life. The etiology of lichen planus is not entirely understood. Yet, immune-mediated mechanisms have been recognized since environmental factors such as hepatitis virus infection, mechanical trauma, psychological stress, or microbiome changes can trigger the disease in genetically susceptible individuals. According to current understanding, lichen planus immunopathogenesis is caused by cell-mediated cytotoxicity, particularly cytotoxic T lymphocytes, whose activity is further influenced by Th1 and IL-23/Th-17 axis. However, other immunocytes and inflammatory pathways complement these mechanisms. This paper presents a comprehensive insight into the actual knowledge about lichen planus, with the causal genetic and environmental factors being discussed, the immunopathogenesis described, and the principal effectors of its inflammatory circuits identified.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 3, 3038
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24033038
URN:NBNurn:nbn:hr:184:490729
Publication2023-02-03
Document URLhttps://www.mdpi.com/1422-0067/24/3/3038
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-15 08:09:05