SUMMARY The use of tyrosine kinase inhibitors is becoming increasingly common in oncological therapy due to their anti-tumor and anti-angiogenic effects. One of the more significant representatives of this group of medications is sunitinib, an oral multi-target inhibitor used in certain forms of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and advanced neuroendocrine pancreatic cancer. In addition to the positive effects of this group of medications, some unwanted effects have also been observed. Depending on the authors, 10% to 30% of patients experienced some form of cardiovascular (CV) event during the application of tyrosine kinase inhibitors. Herein we present the case of a 73-year-old patient who initially received surgery for metastatic cancer in the right kidney, followed by treatment with sunitinib. Approximately eight months after starting this treatment, the patient presented to the Integrated Emergency Hospital Admission department due to chest pains. An electrocardiogram was performed, and suspicion of acute coronary syndrome with ST-segment elevation in the inferior, posterior, and lateral leads was established. Emergency coronarography showed occlusion of the proximal part of the right coronary artery, and treatment continued with primary percutaneous coronary intervention. Given that no significant CV comorbidities had been previously recorded in the patient, a potential link to the application of tyrosine kinase inhibitors was suspected. Examination of other international publications on similar topics indicates a significant incidence of a wide spectrum of CV events associated with these medications. Some studies found that the application of this group of medications leads to increased arterial pressure, arterial stiffness, and reduced elasticity. A case report by Italian authors described a patient who underwent a cardiosurgical bypass procedure after 2 years of sorafenib use, despite having no significant CV comorbidities. These publications and the present case report lead to the conclusion that higher-quality CV monitoring is needed in oncological patients using tyrosine kinase inhibitors with the goal of preventing unwanted events and outcomes.