prikaz prve stranice dokumenta Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
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Scientific paper - Original scientific paper
Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
npj Vaccines, 8 (2023), 1; 8. https://doi.org/10.1038/s41541-023-00602-4
Le-Trilling, Vu Thuy Khanh; Jagnjić, Andreja; Brizić, Ilija; Eilbrecht, Mareike; Wohlgemuth, Kerstin; Rožmanić, Carmen; Herdman, Alan; Hoffmann, Katja; Westendorf, Astrid M.; Hengel, Hartmut; Jonjić, Stipan; Trilling, Mirko

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Le Trilling, V. T. K., Jagnjić, A., Brizić, I., Eilbrecht, M., Wohlgemuth, K., Rožmanić, C. ... Trilling, M. (2023). Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus. npj Vaccines, 8. (1). doi: 10.1038/s41541-023-00602-4

Le Trilling, Vu Thuy Khanh, et al. "Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus." npj Vaccines, vol. 8, no. 1, 2023. https://doi.org/10.1038/s41541-023-00602-4

Le Trilling, Vu Thuy Khanh, Andreja Jagnjić, Ilija Brizić, Mareike Eilbrecht, Kerstin Wohlgemuth, Carmen Rožmanić, Alan Herdman, et al. "Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus." npj Vaccines 8, no. 1 (2023). https://doi.org/10.1038/s41541-023-00602-4

Le Trilling, V. T. K., et al. (2023) 'Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus', npj Vaccines, 8(1). doi: 10.1038/s41541-023-00602-4

Le Trilling VTK, Jagnjić A, Brizić I, Eilbrecht M, Wohlgemuth K, Rožmanić C, and sur.. Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus. npj Vaccines [Internet]. 2023 February 03 [cited 2024 November 29];8(1). doi: 10.1038/s41541-023-00602-4

V. T. K. Le Trilling, et al., "Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus", npj Vaccines, vol. 8, no. 1, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:761822. [Accessed: 29 November 2024]

Metadata
Title (english)Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
AuthorVu Thuy Khanh Le-Trilling
AuthorAndreja Jagnjić
AuthorIlija Brizić
AuthorMareike Eilbrecht
AuthorKerstin Wohlgemuth
AuthorCarmen Rožmanić
AuthorAlan Herdman
AuthorKatja Hoffmann
AuthorAstrid M. Westendorf
AuthorHartmut Hengel
AuthorStipan Jonjić
AuthorMirko Trilling
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus (HCMV) frequently causes congenital infections, resulting in birth defects and developmental disorders. A vaccine is needed, but unavailable. We analyzed the potential of CMV mutants, lacking their STAT2 antagonists to serve as live attenuated vaccine viruses in mice. Infections with attenuated viruses elicited strong ELISA-reactive binding IgG responses and induced neutralizing antibodies as well as antibodies stimulating cellular Fcγ receptors, including the antibody-dependent cellular cytotoxicity (ADCC)-eliciting receptors FcγRIII/CD16 and FcγRIV. Accordingly, vaccinated mice were fully protected against challenge infections. Female mice vaccinated prior to gestation transmitted CMV-specific IgG to their offspring, which protected the progeny from perinatal infections in a mouse model for congenital CMV disease. To define the role of maternal antibodies, female mice either capable or incapable of producing antibodies were vaccinated and subsequently bred to males of the opposite genotype. Challenge infections of the genotypically identical F1 generation revealed the indispensability of maternal antibodies for vaccine-induced protection against cytomegaloviruses.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlenpj Vaccines
Numberingvol. 8, no. 1, 8
e-ISSN2059-0105
DOIhttps://doi.org/10.1038/s41541-023-00602-4
URN:NBNurn:nbn:hr:184:761822
Publication2023-02-03
Document URLhttps://www.nature.com/articles/s41541-023-00602-4
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-02-27 12:13:32