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Scientific paper - Original scientific paper
The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1
Viruses, 14 (2022), 8; 1661. https://doi.org/10.3390/v14081661
Zubković, Andreja; Žarak, Ines; Ratkaj, Ivana; Rokić, Filip; Jekić, Maja; Pribanić Matešić, Marina; Lebrón, Ricardo; Gómez-Martín, Cristina; Lisnić, Berislav; Lisnić Juranić, Vanda; Jonjić, Stipan; Pan, Dongli; Vugrek, Oliver; Hackenberg, Michael; Jurak, Igor More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Zubković, A., Žarak, I., Ratkaj, I., Rokić, F., Jekić, M., Pribanić Matešić, M. ... Jurak, I. (2022). The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1. Viruses, 14. (8). doi: 10.3390/v14081661

Zubković, Andreja, et al. "The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1." Viruses, vol. 14, no. 8, 2022. https://doi.org/10.3390/v14081661

Zubković, Andreja, Ines Žarak, Ivana Ratkaj, Filip Rokić, Maja Jekić, Marina Pribanić Matešić, Ricardo Lebrón, et al. "The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1." Viruses 14, no. 8 (2022). https://doi.org/10.3390/v14081661

Zubković, A., et al. (2022) 'The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1', Viruses, 14(8). doi: 10.3390/v14081661

Zubković A, Žarak I, Ratkaj I, Rokić F, Jekić M, Pribanić Matešić M, and sur.. The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1. Viruses [Internet]. 2022 July 28 [cited 2024 May 14];14(8). doi: 10.3390/v14081661

A. Zubković, et al., "The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1", Viruses, vol. 14, no. 8, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:571870. [Accessed: 14 May 2024]

Metadata
Title (english)The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1
AuthorAndreja Zubković
AuthorInes Žarak
AuthorIvana Ratkaj
AuthorFilip Rokić
AuthorMaja Jekić
AuthorMarina Pribanić Matešić
AuthorRicardo Lebrón
AuthorCristina Gómez-Martín
AuthorBerislav Lisnić
AuthorVanda Lisnić Juranić
AuthorStipan Jonjić
AuthorDongli Pan
AuthorOliver Vugrek
AuthorMichael Hackenberg
AuthorIgor Jurak
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood. In addition, HSV-1 has been found to deregulate host miRNAs, which adds to the complexity of the regulation of efficient virus replication. In this study, we comprehensively addressed the deregulation of host miRNAs by massive-parallel sequencing. We found that only miRNAs expressed from a single cluster, miR-183/96/182, are reproducibly deregulated during productive infection. These miRNAs are predicted to regulate a great number of potential targets involved in different cellular processes and have only 33 shared targets. Among these, members of the FoxO family of proteins were identified as potential targets for all three miRNAs. However, our study shows that the upregulated miRNAs do not affect the expression of FoxO proteins, moreover, these proteins were upregulated in HSV-1 infection. Furthermore, we show that the individual FoxO proteins are not required for efficient HSV-1 replication. Taken together, our results indicate a complex and redundant response of infected cells to the virus infection that is efficiently inhibited by the virus.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleViruses
Numberingvol. 14, no. 8, 1661
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14081661
URN:NBNurn:nbn:hr:184:571870
Publication2022-07-28
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttps://www.mdpi.com/1999-4915/14/8/1661
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-27 12:55:39