prikaz prve stranice dokumenta Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.
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Scientific paper - Original scientific paper
Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.
Cell Reports, 42 (2023), 4; 112395. urn:nbn:hr:184:631681
Kavazović, Inga; Dimitropoulos, Christoforos; Gašparini, Dora; Rončević Filipović, Mari; Barković, Igor; Koster, Jan; Lemmermman A., Niels; Babić, Marina; Cekinović Grbeša, Đurđica; Wensveen M., Felix

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Kavazović, I., Dimitropoulos, C., Gašparini, D., Rončević Filipović, M., Barković, I., Koster, J. ... Wensveen M., F. (2023). Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.. Cell Reports, 42. (4). Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:631681

Kavazović, Inga, et al. "Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.." Cell Reports, vol. 42, no. 4, 2023. https://urn.nsk.hr/urn:nbn:hr:184:631681

Kavazović, Inga, Christoforos Dimitropoulos, Dora Gašparini, Mari Rončević Filipović, Igor Barković, Jan Koster, Niels Lemmermman A., Marina Babić, Đurđica Cekinović Grbeša and Felix Wensveen M.. "Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.." Cell Reports 42, no. 4 (2023). https://urn.nsk.hr/urn:nbn:hr:184:631681

Kavazović, I., et al. (2023) 'Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.', Cell Reports, 42(4). Available at: https://urn.nsk.hr/urn:nbn:hr:184:631681 (Accessed 21 May 2024)

Kavazović I, Dimitropoulos C, Gašparini D, Rončević Filipović M, Barković I, Koster J, and sur.. Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.. Cell Reports [Internet]. 2023 April 25 [cited 2024 May 21];42(4). Available at: https://urn.nsk.hr/urn:nbn:hr:184:631681

I. Kavazović, et al., "Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.", Cell Reports, vol. 42, no. 4, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:631681. [Accessed: 21 May 2024]

Metadata
Title (english)Vaccination provides superior in vivo recall capacity of SARS-CoV-2 specific memory CD8 T cells on April 02, 2023.
AuthorInga Kavazović
AuthorChristoforos Dimitropoulos
AuthorDora Gašparini https://orcid.org/0000-0002-0503-9516
AuthorMari Rončević Filipović
AuthorIgor Barković
AuthorJan Koster
AuthorNiels Lemmermman A.
AuthorMarina Babić
AuthorĐurđica Cekinović Grbeša
AuthorFelix Wensveen M.
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Memory CD8 T cells play an important role in the protection against breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether the route of antigen exposure impacts these cells at a functional level is incompletely characterized. Here, we compare the memory CD8 T cell response against a common SARS-CoV-2 epitope after vaccination, infection, or both. CD8 T cells demonstrate comparable functional capacity when restimulated directly ex vivo, independent of the antigenic history. However, analysis of T cell receptor usage shows that vaccination results in a narrower scope than infection alone or in combination with vaccination. Importantly, in an in vivo recall model, memory CD8 T cells from infected individuals show equal proliferation but secrete less tumor necrosis factor (TNF) compared with those from vaccinated people. This difference is negated when infected individuals have also been vaccinated. Our findings shed more light on the differences in susceptibility to re-infection after different routes of SARS-CoV-2 antigen exposure
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Reports
Numberingvol. 42, no. 4, 112395
p-ISSN2211-1247
URN:NBNurn:nbn:hr:184:631681
Publication2023-04-25
ProjectNumber: IP-CORONA-2020-04-2045
Title (croatian): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Title (english): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Acronym: CORONAWAI
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP-CORONA
ProjectNumber: IP-2020-02-7928
Title (croatian): Utjecaj šećerne bolesti tipa 2 i njezinog liječenja na funkciju limfocita
Acronym: DIABOLYC
Leader: Tamara Turk Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Title (english): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Acronym: T-MEMORY
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://bib.irb.hr/1268783
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-05-04 10:48:30