prikaz prve stranice dokumenta Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas
  Download
PDF 249.34 KB
Scientific paper - Original scientific paper
Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas
Collegium antropologicum, 35 - supplement 2 (2011), 2; 7-10. urn:nbn:hr:184:867704
Fučkar Čupić, Dora; Cini Tešar, Eleonora; Matušan Ilijaš, Koviljka; Nemrava, Johan; Kovačević, Marinko; Mustać, Elvira

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Fučkar Čupić, D., Cini Tešar, E., Matušan Ilijaš, K., Nemrava, J., Kovačević, M. & Mustać, E. (2011). Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas. Collegium antropologicum, 35 - supplement 2. (2), 7-10. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:867704

Fučkar Čupić, Dora, et al. "Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas." Collegium antropologicum, vol. 35 - supplement 2, no. 2, 2011, pp. 7-10. https://urn.nsk.hr/urn:nbn:hr:184:867704

Fučkar Čupić, Dora, Eleonora Cini Tešar, Koviljka Matušan Ilijaš, Johan Nemrava, Marinko Kovačević and Elvira Mustać. "Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas." Collegium antropologicum 35 - supplement 2, no. 2 (2011): 7-10. https://urn.nsk.hr/urn:nbn:hr:184:867704

Fučkar Čupić, D., et al. (2011) 'Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas', Collegium antropologicum, 35 - supplement 2(2), pp. 7-10. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867704 (Accessed 08 November 2024)

Fučkar Čupić D, Cini Tešar E, Matušan Ilijaš K, Nemrava J, Kovačević M, Mustać E. Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas. Collegium antropologicum [Internet]. 2011 [cited 2024 November 08];35 - supplement 2(2):7-10. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867704

D. Fučkar Čupić, E. Cini Tešar, K. Matušan Ilijaš, J. Nemrava, M. Kovačević and E. Mustać, "Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas", Collegium antropologicum, vol. 35 - supplement 2, no. 2, pp. 7-10, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:867704. [Accessed: 08 November 2024]

Metadata
Title (english)Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas
AuthorDora Fučkar Čupić
AuthorEleonora Cini Tešar
AuthorKoviljka Matušan Ilijaš
AuthorJohan Nemrava
AuthorMarinko Kovačević
AuthorElvira Mustać
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
The matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases that are secreted as inactive precursors, which are activated by cleavage of an N-terminal pro-peptide. Their basic mechanisms of action include cancer cell growth, differentiation, apoptosis, migration and invasion, and the regulation of tumour angiogenesis and immune surveillance. The expression of MMP2 and MMP9 has been associated with high potential of metastasis in several human carcinomas including breast cancer. The 29 female patients, 9 premenopausal and 20 postmenopausal, aged from 37 to 79 years were included in this study. Tissue samples were examined in 29 primary and 48 recurrent carcinomas using the tissue microarrays which included 102 cores of primary breast carcinomas and 96 of recurrent breast carcinomas. Immunohistochemistry determined a pattern of expression for MMP9. The staining was diffuse cytoplasmic, strong, moderate, faint/weak and negative. The majority of the breast carcinomas stained homogenously for MMP9 on tumor cells. Statistically significant correlation was found for the expression of MMP9 between primary and recurrent breast carcinomas in general (p<0.001) and in tumors that were grouped as recurrence before (p=0.039) and after 24 months (p<0.001). Strong expression of MMP9 was observed in primary tumors that recurred after 24 months, median: 162.5 (score range 0–300) and those tumors that recurred before 24 months of the initial diagnosis, median: 102.5 (score range 0–250) (p=0.026).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 35 - supplement 2, no. 2, pp. 7-10
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:867704
Publication2011
Document URLhttps://hrcak.srce.hr/72215
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-05-17 12:16:34