prikaz prve stranice dokumenta VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer
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Scientific paper - Original scientific paper
VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer
International Journal of Surgical Pathology, 14 (2016), 1; 49-55. https://doi.org/10.1177/106689690601400109
Fučkar, Dora; Dekanić, Andrea; Štifter, Sanja; Mustać, Elvira; Krstulja, Mira; Dobrila, Fran; Jonjić, Nives

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Fučkar, D., Dekanić, A., Štifter, S., Mustać, E., Krstulja, M., Dobrila, F. & Jonjić, N. (2016). VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer. International Journal of Surgical Pathology, 14. (1), 49-55. doi: 10.1177/106689690601400109

Fučkar, Dora, et al. "VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer." International Journal of Surgical Pathology, vol. 14, no. 1, 2016, pp. 49-55. https://doi.org/10.1177/106689690601400109

Fučkar, Dora, Andrea Dekanić, Sanja Štifter, Elvira Mustać, Mira Krstulja, Fran Dobrila and Nives Jonjić. "VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer." International Journal of Surgical Pathology 14, no. 1 (2016): 49-55. https://doi.org/10.1177/106689690601400109

Fučkar, D., et al. (2016) 'VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer', International Journal of Surgical Pathology, 14(1), pp. 49-55. doi: 10.1177/106689690601400109

Fučkar D, Dekanić A, Štifter S, Mustać E, Krstulja M, Dobrila F, and sur.. VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer. International Journal of Surgical Pathology [Internet]. 2016 July 27 [cited 2024 April 29];14(1):49-55. doi: 10.1177/106689690601400109

D. Fučkar, et al., "VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer", International Journal of Surgical Pathology, vol. 14, no. 1, pp. 49-55, July 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:518507. [Accessed: 29 April 2024]

Metadata
Title (english)VEGF Expression is Associated with Negative Estrogen Receptor Status in Patients with Breast Cancer
AuthorDora Fučkar
AuthorAndrea Dekanić
AuthorSanja Štifter
AuthorElvira Mustać
AuthorMira Krstulja
AuthorFran Dobrila
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
The aim of this study was to analyze the association between vascular endothelial growth factor (VEGF) expression on tumor cells and other clinicopathologic parameters in breast cancer that could give additional information on its prognostic significance. Immunohistochemical analysis of expression of VEGF, estrogen (ER) and progesterone receptor (PR), HER-2/neu, and Ki67 was performed in 233 breast cancers. VEGF expression estimated semiquantitatively was correlated with all the above-mentioned parameters as well as with clinicopathologic characteristics of breast cancer such as menopausal status of patients, tumor size, histologic and nuclear grade, vascular invasion, and lymph node status. Most of the tumor cells and some stromal components expressed VEGF. A higher percentage of VEGF-positive tumor cells was present in premenopausal patients and in ER-negative tumors. In postmenopausal patients tumors with a higher expression of VEGF were associated not only with ER-negative but also with HER-2/neu-positive tumor cells. These ER-negative tumors were characterized by a higher proliferative activity. Angiogenic switch as well as proliferative activity of breast cancer cells probably are unfavorably dependent on estrogen activity. This negative correlation between VEGF expression and ER status may not only shed more light on tumor biology but may also have future therapeutic implications.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Surgical Pathology
Numberingvol. 14, no. 1, pp. 49-55
p-ISSN1066-8969
e-ISSN1940-2465
DOIhttps://doi.org/10.1177/106689690601400109
URN:NBNurn:nbn:hr:184:518507
Publication2016-07-27
Document URLhttp://journals.sagepub.com/doi/10.1177/106689690601400109
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-05-18 11:52:38