prikaz prve stranice dokumenta Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma
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Scientific paper - Original scientific paper
Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma
Clinical and Experimental Dermatology, 28 (2003), 3; 310-314. https://doi.org/10.1046/j.1365-2230.2003.01270.x
Jonjić, Nives; Zamolo, Gordana; Štifter, Sanja; Fučkar, Dora; Gruber, Franjo; Sasso, F.; Rizzardi, C.; Melato, M.

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Cite this document

Jonjić, N., Zamolo, G., Štifter, S., Fučkar, D., Gruber, F., Sasso, F. ... Melato, M. (2003). Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma. Clinical and Experimental Dermatology, 28. (3), 310-314. doi: 10.1046/j.1365-2230.2003.01270.x

Jonjić, Nives, et al. "Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma." Clinical and Experimental Dermatology, vol. 28, no. 3, 2003, pp. 310-314. https://doi.org/10.1046/j.1365-2230.2003.01270.x

Jonjić, Nives, Gordana Zamolo, Sanja Štifter, Dora Fučkar, Franjo Gruber, F. Sasso, C. Rizzardi and M. Melato. "Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma." Clinical and Experimental Dermatology 28, no. 3 (2003): 310-314. https://doi.org/10.1046/j.1365-2230.2003.01270.x

Jonjić, N., et al. (2003) 'Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma', Clinical and Experimental Dermatology, 28(3), pp. 310-314. doi: 10.1046/j.1365-2230.2003.01270.x

Jonjić N, Zamolo G, Štifter S, Fučkar D, Gruber F, Sasso F, and sur.. Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma. Clinical and Experimental Dermatology [Internet]. 2003 [cited 2024 November 08];28(3):310-314. doi: 10.1046/j.1365-2230.2003.01270.x

N. Jonjić, et al., "Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma", Clinical and Experimental Dermatology, vol. 28, no. 3, pp. 310-314, 2003. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:278284. [Accessed: 08 November 2024]

Metadata
Title (english)Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma
AuthorNives Jonjić
AuthorGordana Zamolo
AuthorSanja Štifter
AuthorDora Fučkar
AuthorFranjo Gruber
AuthorF. Sasso
AuthorC. Rizzardi
AuthorM. Melato
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Depth of invasion and stage of the disease are well known prognostic indicators in cutaneous melanoma (CM). However, the role of other parameters, such as the variations in cytomorphology of melanocyte tumours, mitotic activity and angiogenesis is still open to question. The aim of this study was to analyse proliferation by mitotic activity index (MAI) and immunostaining of proliferating cell nuclear antigen (PCNA), and the intensity of neovascularization (microvessel density ; MVD) in CM clinical stage I in relation to epithelioid, spindle and nevoid cell type, histological type (superficial spreading melanoma and nodular melanoma), Clark's level and Breslow thickness. Finally, the role of all parameters in the prognosis of CM was evaluated. Statistical analysis demonstrated that cytological characteristics of CM correlate only with Clark's level, while histological types correlate with MAI, PCNA and MVD. MAI and PCNA also showed correlation between groups according to Clark's level and Breslow thickness. Finally, tumour cell PCNA was found to correlate with MVD. Survival of patients with CM correlated significantly with MAI. These results suggest that cytological variation, histological type, PCNA and MVD alone are not independent prognostic parameters, whereas MAI is a potentially important prognostic marker in CM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical and Experimental Dermatology
Numberingvol. 28, no. 3, pp. 310-314
p-ISSN0307-6938
e-ISSN1365-2230
DOIhttps://doi.org/10.1046/j.1365-2230.2003.01270.x
URN:NBNurn:nbn:hr:184:278284
Publication2003
Document URLhttp://bib.irb.hr/136050
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-05-18 12:29:13