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Scientific paper - Review paper
Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications
Journal of Cardiovascular Development and Disease, 10 (2023), 5; 213. https://doi.org/10.3390/jcdd10050213
Knežević, Danijel; Ćurko-Cofek, Božena; Batinac, Tanja; Laškarin, Gordana; Rakić, Marijana; Šoštarič, Maja; Zdravković, Marko; Šustić, Alan; Sotošek, Vlatka; Batičić, Lara

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Knežević, D., Ćurko Cofek, B., Batinac, T., Laškarin, G., Rakić, M., Šoštarič, M. ... Batičić, L. (2023). Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications. Journal of Cardiovascular Development and Disease, 10. (5). doi: 10.3390/jcdd10050213

Knežević, Danijel, et al. "Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications." Journal of Cardiovascular Development and Disease, vol. 10, no. 5, 2023. https://doi.org/10.3390/jcdd10050213

Knežević, Danijel, Božena Ćurko Cofek, Tanja Batinac, Gordana Laškarin, Marijana Rakić, Maja Šoštarič, Marko Zdravković, Alan Šustić, Vlatka Sotošek and Lara Batičić. "Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications." Journal of Cardiovascular Development and Disease 10, no. 5 (2023). https://doi.org/10.3390/jcdd10050213

Knežević, D., et al. (2023) 'Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications', Journal of Cardiovascular Development and Disease, 10(5). doi: 10.3390/jcdd10050213

Knežević D, Ćurko Cofek B, Batinac T, Laškarin G, Rakić M, Šoštarič M, and sur.. Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications. Journal of Cardiovascular Development and Disease [Internet]. 2023 May 13 [cited 2024 April 29];10(5). doi: 10.3390/jcdd10050213

D. Knežević, et al., "Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications", Journal of Cardiovascular Development and Disease, vol. 10, no. 5, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:475688. [Accessed: 29 April 2024]

Metadata
Title (english)Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications
AuthorDanijel Knežević
AuthorBožena Ćurko-Cofek
AuthorTanja Batinac
AuthorGordana Laškarin
AuthorMarijana Rakić
AuthorMaja Šoštarič
AuthorMarko Zdravković
AuthorAlan Šustić
AuthorVlatka Sotošek
AuthorLara Batičić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cardiac surgery is one of the highest-risk procedures, usually involving cardiopulmonary bypass and commonly inducing endothelial injury that contributes to the development of perioperative and postoperative organ dysfunction. Substantial scientific efforts are being made to unravel the complex interaction of biomolecules involved in endothelial dysfunction to find new therapeutic targets and biomarkers and to develop therapeutic strategies to protect and restore the endothelium. This review highlights the current state-of-the-art knowledge on the structure and function of the endothelial glycocalyx and mechanisms of endothelial glycocalyx shedding in cardiac surgery. Particular emphasis is placed on potential strategies to protect and restore the endothelial glycocalyx in cardiac surgery. In addition, we have summarized and elaborated the latest evidence on conventional and potential biomarkers of endothelial dysfunction to provide a comprehensive synthesis of crucial mechanisms of endothelial dysfunction in patients undergoing cardiac surgery, and to highlight their clinical implications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Cardiovascular Development and Disease
Numberingvol. 10, no. 5, 213
e-ISSN2308-3425
DOIhttps://doi.org/10.3390/jcdd10050213
URN:NBNurn:nbn:hr:184:475688
Publication2023-05-13
ProjectNumber: uniri-biomed-18-40
Title (croatian): Karakterizacija endotelne disfunkcije i uloga IL-18 u razvoju ishemijsko reperfuzijske ozljede nakon kirurške revaskularizacije miokarda
Jurisdiction: Croatia
Document URLhttps://www.mdpi.com/2308-3425/10/5/213
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-05-19 06:46:03