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Scientific paper - Original scientific paper
Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy
Cancers, 15 (2023), 11; 3052. https://doi.org/10.3390/cancers15113052
Golčić, Marin; Simetić, Luka; Herceg, Davorin; Blažičević, Krešimir; Kenđel Jovanović, Gordana; Dražić, Ivan; Belančić, Andrej; Skočibušić, Nataša; Palčevski, Dora; Rubinić, Igor; Vlahović-Palčevski, Vera; Majnarić, Tea; Dobrila-Dintinjana, Renata; Pleština, Stjepko

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Golčić, M., Simetić, L., Herceg, D., Blažičević, K., Kenđel Jovanović, G., Dražić, I. ... Pleština, S. (2023). Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy. Cancers, 15. (11). doi: 10.3390/cancers15113052

Golčić, Marin, et al. "Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy." Cancers, vol. 15, no. 11, 2023. https://doi.org/10.3390/cancers15113052

Golčić, Marin, Luka Simetić, Davorin Herceg, Krešimir Blažičević, Gordana Kenđel Jovanović, Ivan Dražić, Andrej Belančić, et al. "Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy." Cancers 15, no. 11 (2023). https://doi.org/10.3390/cancers15113052

Golčić, M., et al. (2023) 'Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy', Cancers, 15(11). doi: 10.3390/cancers15113052

Golčić M, Simetić L, Herceg D, Blažičević K, Kenđel Jovanović G, Dražić I, and sur.. Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy. Cancers [Internet]. 2023 June 04 [cited 2024 April 28];15(11). doi: 10.3390/cancers15113052

M. Golčić, et al., "Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy", Cancers, vol. 15, no. 11, June 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:283235. [Accessed: 28 April 2024]

Metadata
Title (english)Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy
AuthorMarin Golčić https://orcid.org/0000-0002-3388-4813
AuthorLuka Simetić
AuthorDavorin Herceg
AuthorKrešimir Blažičević
AuthorGordana Kenđel Jovanović
AuthorIvan Dražić
AuthorAndrej Belančić
AuthorNataša Skočibušić
AuthorDora Palčevski
AuthorIgor Rubinić
AuthorVera Vlahović-Palčevski
AuthorTea Majnarić
AuthorRenata Dobrila-Dintinjana
AuthorStjepko Pleština
Author's institution(Clinical Hospital Center Rijeka)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiotherapy and Oncology
Abstract (english)
Immunotherapy has improved the prognosis of metastatic melanoma patients, although most patients do not achieve a complete response. While specific gut microbiome and dietary habits might influence treatment success, there is a lack of concordance between the studies, potentially due to dichotomizing patients only into responders and non-responders. The aim of this study was to elucidate whether metastatic melanoma patients with complete and sustained response to immunotherapy exhibit differences in gut microbiome composition among themselves, and whether those differences were associated with specific dietary habits. Shotgun metagenomic sequencing revealed that patients who exhibited a complete response after more than 9 months of treatment (late responders) exhibited a significantly higher beta-diversity (p = 0.02), with a higher abundance of Coprococcus comes (LDA 3.548, p = 0.010), Bifidobacterium pseudocatenulatum (LDA 3.392, p = 0.024), and lower abundance of Prevotellaceae (p = 0.04) compared to early responders. Furthermore, late responders exhibited a different diet profile, with a significantly lower intake of proteins and sweets and a higher intake of flavones (p < 0.05). The research showed that metastatic melanoma patients with a complete and sustained response to immunotherapy were a heterogeneous group. Patients with a late complete response exhibited microbiome and dietary habits which were previously associated with an improved response to immunotherapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCancers
Numberingvol. 15, no. 11, 3052
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers15113052
URN:NBNurn:nbn:hr:184:283235
Publication2023-06-04
Document URLhttps://www.mdpi.com/2072-6694/15/11/3052
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-06-19 12:11:09