prikaz prve stranice dokumenta Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells
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Scientific paper - Original scientific paper
Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells
American Journal of Reproductive Immunology, 74 (2015), 1; 38-53. https://doi.org/10.1111/aji.12374
Redžovic, Arnela; Gulić, Tamara; Laškarin, Gordana; Eminović, Senija; Haller, Herman; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Redžovic, A., Gulić, T., Laškarin, G., Eminović, S., Haller, H. & Rukavina, D. (2015). Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells. American Journal of Reproductive Immunology, 74. (1), 38-53. doi: 10.1111/aji.12374

Redžovic, Arnela, et al. "Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells." American Journal of Reproductive Immunology, vol. 74, no. 1, 2015, pp. 38-53. https://doi.org/10.1111/aji.12374

Redžovic, Arnela, Tamara Gulić, Gordana Laškarin, Senija Eminović, Herman Haller and Daniel Rukavina. "Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells." American Journal of Reproductive Immunology 74, no. 1 (2015): 38-53. https://doi.org/10.1111/aji.12374

Redžovic, A., et al. (2015) 'Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells', American Journal of Reproductive Immunology, 74(1), pp. 38-53. doi: 10.1111/aji.12374

Redžovic A, Gulić T, Laškarin G, Eminović S, Haller H, Rukavina D. Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells. American Journal of Reproductive Immunology [Internet]. 2015 July [cited 2024 November 09];74(1):38-53. doi: 10.1111/aji.12374

A. Redžovic, T. Gulić, G. Laškarin, S. Eminović, H. Haller and D. Rukavina, "Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells", American Journal of Reproductive Immunology, vol. 74, no. 1, pp. 38-53, July 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:440188. [Accessed: 09 November 2024]

Metadata
Title (english)Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells
AuthorArnela Redžovic
AuthorTamara Gulić
AuthorGordana Laškarin
AuthorSenija Eminović
AuthorHerman Haller
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
ProblemThe aim of the study was to assess possible binding of a mixture of constitutive Hsc70 and inducible Hsp70 forms (HSP70) to Toll-like receptor (TLR) 4 and CD91 receptors on decidual CD1a(+) dendritic cells (DCs) and their influence on DCs maturation status. Method of studyImmunohistology and immunofluorescence of paraffin-embedded first trimetester and term pregnancy decidua were performed together with flow cytometry detection of antigens in DCs after stimulation of decidual mononuclear cells with HSP70. ResultsHsc70 and Hsp70 labeling revealed intracellular and nuclear staining in trophoblast cells. The numbers of Hsc70(+) and Hsp70(+) cells of decidual tissue were higher in early pregnancy decidua than in decidua at term. HSP70 binds CD91 and TLR4 receptors on CD1a(+) DCs and increased the expression of CD83, HLA-DR, CD80, and CD86, but decreased CC receptor (CCR) 5. HSP70 increased CC ligand (CCL) 3 and CCL22. HSP70 in the concentration of 1g/mL increased the percentage of interferon- and interleukin (IL)-15-expressing cells over the cells expressing IL-4. ConclusionHSP70 binds CD91 and TLR4 on decidual CD1a(+) DCs, causes their maturation, and increases IL-15 in the context of Th1 cytokine/chemokine domination, which could support immune response harmful for ongoing pregnancy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 74, no. 1, pp. 38-53
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/aji.12374
URN:NBNurn:nbn:hr:184:440188
Publication2015-07
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/aji.12374
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-06-26 12:32:18