Transgenderism is a phenomenon in which one’s gender identity does not correspond their biological sex, that is, their gender role. Sex is an anatomical determinant and gender has a social and psychological category and refers to the feeling of belonging to a certain gender. When someone’s biological sex is not in accordance with how they feel it is called transgenderism, and if that feeling is the cause of stress and dissatisfaction it is accompanied with gender dysphoria. Gender dysphoria can occur in childhood, adolescence and adulthood, that is why clinical approach is adapted to all of the age groups. Mostly the gender dysphoria from childhood does not continue in adolescence, but if it continues or intensifies in adolescence, then there is a risk of continuation in adulthood. New and worrying data is that within the few last years gender dysphoria and transgenderism have been occurring among adolescents who have no history of gender dysphoria, especially among the female population. Medical experts need to additionally investigate potential causes, the most adequate approach and methods of treatment of dysphoria and transgenderism in population of these adolescents. A brief overview of mentioned is discussed in this paper. With the fact that the number of cases of transgenderism in adolescent population is increasing, and in parallel, increased social transactivism can be observed, an overview of additional factors that could point to transgenderism as a form of adolescent crisis is also listed in this paper