| Abstract | Cilj rada: Analizirati funkcionalni i onkološki ishod bolesnika liječenih radi papilarnog karcinoma štitne žlijezde.
Materijali i metode: U retrospektivno istraživanje uključeno je 104 bolesnika liječenih radi papilarnog karcinoma štitne žlijezde u razdoblju od 2015 do 2023 godine. Funkcionalni ishod je analiziran prisustvom ozlijede rekurentnog živca, hipokalcemijom, krvarenjima i infekcijama. Onkološki ishod je prikazan Kaplan-Meirovim krivuljama ukupnog i bolest specifičnog preživljenja.
Rezultati: Od ukupno 104 bolesnika, 87 (83,7%) bilo je ženskog spola, a 17 (16,3%) muškog spola. Prosječna dob analiziranih bolesnika bila je 50 godina. Bolesnici su analizirani prema postupku operacije te je kod 73% slučajeva učinjen zahvat totalne tireidektomije, u 25% samo zahvat lobektomije te u 2% zahvat kompletne tireidektomije. Analizajući komplikacije operacije, u 9,6% bolesnika došlo je do razvoja unilateralne pareze glasnica, a kod 1,9% bolesnika razvila se bilateralna pareza glasnica. 1,9% bolesnika kao komplikaciju imalo je krvarenje pa je učinjena revizijska operacija. Infekcije nisu zabilježene. Kod 9,4% bolesnika registrirana je hipokalcemija. od čega je 97,6% bolesnika imalo prolaznu hipokalcemiju, a u 2,4% slučajeva je bila potrebna trajna nadomjesna terapija. 7,7% bolesnika je postoperacijski imalo disfagiju. 7,69% bolesnika razvilo je neki sekundarni karcinom. 3,9% bolesnika je preminulo. 50% bolesnika od samih posljedica karcinoma štitnjače, a 50% od drugog uzroka koji su nepovezani s primarnom bolesti. Recidiv tumora razvilo je 3,8% bolesnika te su svi bili na regionalnoj razini.
Zaključak: Papilarni karcinom štitnjače najčešći je karcinom štitnjače. Napretkom medicine i češćom upotrebom ultrazvuka vrata u sistemskim pregledima češće se otkriva te u relativno ranom stadiju što vodi boljem funkcionalnom i onkološkom ishodu. |
| Abstract (english) | Objective: To analyze the functional and oncological outcomes of patients treated for papillary thyroid cancer.
Materials and methods: The retrospective study included 104 patients treated for papillary thyroid cancer in the period from 2015 to 2023. The functional outcome was analyzed by the presence of recurrent nerve injury, hypocalcemia, bleeding, and infections. The oncological outcome is shown by Kaplan-Meir curves of overall and disease-specific survival.
Results: Out of a total of 104 patients, 87 (83.7%) were female and 17 (16.3%) were male. The average age of the analyzed patients was 50 years. The patients were analyzed according to the surgical procedure. In 73% of patients, was performed total thyroidectomy, in 25% a lobectomy, and in 2% was performed a complete thyroidectomy. Analyzing the complications of the operation, 9.6% of patients developed unilateral vocal fold paresis, and 1.9% of patients developed bilateral vocal fold paresis. 1.9% of patients had bleeding as a complication, so revision surgery had to be done. No infections were recorded. Hypocalcemia was registered in 9.4% of patients. of which 97.6% of patients had transient hypocalcemia, and 2.4% of patients required permanent replacement therapy. 7.7% of patients had dysphagia postoperatively. 7.69% of patients developed some secondary cancer. 3.9% of patients died. 50% of patients from the very consequences of thyroid cancer, and 50% from another cause unrelated to the primary disease. Tumor recurrence developed in 3.8% of patients, and all of them were at the regional level.
Conclusion: Papillary thyroid cancer is the most common thyroid cancer. With the progress of medicine and the more frequent use of neck ultrasound in systemic examinations, it is detected more often and at a relatively early stage, which leads to a better functional and oncological outcome. |
