prikaz prve stranice dokumenta Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?
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Scientific paper - Review paper
Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?
HEPATO-GASTROENTEROLOGY, 62 (2015), 139; 585-589. https://doi.org/10.5754/hge15033a
Čubranic, Aleksandar; Redžović, Arnela; Dobrila-Dintinjana, Renata; Vukelić, Jelena; Dintinjana, Marijan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Čubranic, A., Redžović, A., Dobrila Dintinjana, R., Vukelić, J. & Dintinjana, M. (2015). Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?. HEPATO-GASTROENTEROLOGY, 62. (139), 585-589. doi: 10.5754/hge15033a

Čubranic, Aleksandar, et al. "Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?." HEPATO-GASTROENTEROLOGY, vol. 62, no. 139, 2015, pp. 585-589. https://doi.org/10.5754/hge15033a

Čubranic, Aleksandar, Arnela Redžović, Renata Dobrila Dintinjana, Jelena Vukelić and Marijan Dintinjana. "Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?." HEPATO-GASTROENTEROLOGY 62, no. 139 (2015): 585-589. https://doi.org/10.5754/hge15033a

Čubranic, A., et al. (2015) 'Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?', HEPATO-GASTROENTEROLOGY, 62(139), pp. 585-589. doi: 10.5754/hge15033a

Čubranic A, Redžović A, Dobrila Dintinjana R, Vukelić J, Dintinjana M. Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?. HEPATO-GASTROENTEROLOGY [Internet]. 2015 [cited 2024 May 10];62(139):585-589. doi: 10.5754/hge15033a

A. Čubranic, A. Redžović, R. Dobrila Dintinjana, J. Vukelić and M. Dintinjana, "Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?", HEPATO-GASTROENTEROLOGY, vol. 62, no. 139, pp. 585-589, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:074028. [Accessed: 10 May 2024]

Metadata
Title (english)Mystery Story about Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) are Disguised?
AuthorAleksandar Čubranic
AuthorArnela Redžović
AuthorRenata Dobrila-Dintinjana
AuthorJelena Vukelić
MBZ: 292473
AuthorMarijan Dintinjana
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In this review we would like to focus our attention upon very controversial reports on Erythropoietin (Epo) and Erythropoietin Receptor (EpoR) expression in cancer patients. The effects of Epo on cancerous tissues are poorly understood. Hypoxia results in an increase in the level of the production of both Epo and EpoR via activation of the hypoxia- inducible factor 1 (HIF-1) pathway. HIF-1 alpha, promotes the expression of vascular endothelial growth factor (VEGF). The signaling through VEGF in both a paracrine and an autocrine manner is required for the homeostasis of adult vessels. Macrophages stimulate vessel sprouting via a soluble factor other than VEGF, rather than through direct contact with endothelial cells. The intriguing questions are set about many researches to link Epo/EpoR expression and function in order to establish one of the mechanisms of tumor growth, disease progression of cancer patient. However, it is uncertain role in tumour angiogenesis as promoter and stimulator of tumour growth which should need to be furtherly validated.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleHEPATO-GASTROENTEROLOGY
Numberingvol. 62, no. 139, pp. 585-589
p-ISSN0172-6390
DOIhttps://doi.org/10.5754/hge15033a
URN:NBNurn:nbn:hr:184:074028
Publication2015
Document URLhttp://bib.irb.hr/998053
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-06-30 07:54:32