prikaz prve stranice dokumenta Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells
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Scientific paper - Original scientific paper
Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells
Journal of Reproductive Immunology, 88 (2011), 1; 12-23. https://doi.org/10.1016/j.jri.2010.10.001
Laškarin, Gordana; Redžovic, Arnela; Vlastelić, Ivan; Haller, Herman; Medančić, Suzana Sršen; Solinas, Graziella; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Laškarin, G., Redžovic, A., Vlastelić, I., Haller, H., Medančić, S. S., Solinas, G. & Rukavina, D. (2011). Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells. Journal of Reproductive Immunology, 88. (1), 12-23. doi: 10.1016/j.jri.2010.10.001

Laškarin, Gordana, et al. "Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells." Journal of Reproductive Immunology, vol. 88, no. 1, 2011, pp. 12-23. https://doi.org/10.1016/j.jri.2010.10.001

Laškarin, Gordana, Arnela Redžovic, Ivan Vlastelić, Herman Haller, Suzana Sršen Medančić, Graziella Solinas and Daniel Rukavina. "Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells." Journal of Reproductive Immunology 88, no. 1 (2011): 12-23. https://doi.org/10.1016/j.jri.2010.10.001

Laškarin, G., et al. (2011) 'Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells', Journal of Reproductive Immunology, 88(1), pp. 12-23. doi: 10.1016/j.jri.2010.10.001

Laškarin G, Redžovic A, Vlastelić I, Haller H, Medančić SS, Solinas G, and sur.. Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells. Journal of Reproductive Immunology [Internet]. 2011 [cited 2024 April 30];88(1):12-23. doi: 10.1016/j.jri.2010.10.001

G. Laškarin, et al., "Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells", Journal of Reproductive Immunology, vol. 88, no. 1, pp. 12-23, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:632689. [Accessed: 30 April 2024]

Metadata
Title (english)Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells
AuthorGordana Laškarin
AuthorArnela Redžovic
AuthorIvan Vlastelić
AuthorHerman Haller
AuthorSuzana Sršen Medančić
AuthorGraziella Solinas
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Tumor-associated glycoprotein-72 (TAG-72) is physiologically present in secretory phase endometrium, but its presence and possible immunological role in early normal human pregnancy decidua has not received attention. The double labeling of paraffin-embedded early pregnancy decidua sections using B-72.4 anti-TAG-72 mAb and MNF 116 anticytokeratin mAb revealed the absence of TAG-72 in uterine decidua of normal and pathological pregnancies (non-embryonic pregnancy and missed abortion) at the implantation sites, although it was present in epithelial cells at and away from the tubal implantation site of an ectopic pregnancy. TAG-72 binds and internalizes by reacting with the mannose receptor (MR-CD206) or with DC-specific ICAM reacting non-integrin (DC-SIGN-CD209) on decidual CD1a+ cells. Decidual CD1a+ cells stimulated with TAG-72 decreased CD83 expression and diminished IL-15 and IFN- intracellular production. TAG-72-treated CD1a+ cells decreased IFN- production in syngenic decidual and allogenic cord blood T cells even in the presence of lipopolysaccharide. TAG-72- and lipopolysaccharide-pre-treated CD1a+ cells significantly increased IL-4 expression in allogenic cord blood T cells. TAG-72 increased allogenic cord blood T cell proliferation, mediated by decidual CD1a+ cells, compared with its effect on the proliferation of syngenic decidual T cells. All these data emphasize the anti-inflammatory properties of TAG-72-treated decidual CD1a+ cells in terms of their interaction with T cells. Thus, the absence of TAG-72 at the maternal–fetal interface during early pregnancy could lead to a mild pro-inflammatory response that may be beneficial for pregnancy success and trophoblast growth control.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Reproductive Immunology
Numberingvol. 88, no. 1, pp. 12-23
p-ISSN0165-0378
DOIhttps://doi.org/10.1016/j.jri.2010.10.001
URN:NBNurn:nbn:hr:184:632689
Publication2011
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0165037810003852
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-06-30 08:45:39