prikaz prve stranice dokumenta Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy
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Scientific paper - Original scientific paper
Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy
American Journal of Reproductive Immunology, 64 (2010); 347-358. https://doi.org/10.1111/j.1600-0897.2010.00844.x
Laškarin, Gordana; Redžovic, Arnela; Vukelić, Petar; Veljković, Danijela; Gulić, Tamara; Haller, Herman; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Laškarin, G., Redžovic, A., Vukelić, P., Veljković, D., Gulić, T., Haller, H. & Rukavina, D. (2010). Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy. American Journal of Reproductive Immunology, 64., 347-358. doi: 10.1111/j.1600-0897.2010.00844.x

Laškarin, Gordana, et al. "Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy." American Journal of Reproductive Immunology, vol. 64, 2010, pp. 347-358. https://doi.org/10.1111/j.1600-0897.2010.00844.x

Laškarin, Gordana, Arnela Redžovic, Petar Vukelić, Danijela Veljković, Tamara Gulić, Herman Haller and Daniel Rukavina. "Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy." American Journal of Reproductive Immunology 64 (2010): 347-358. https://doi.org/10.1111/j.1600-0897.2010.00844.x

Laškarin, G., et al. (2010) 'Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy', American Journal of Reproductive Immunology, 64, pp. 347-358. doi: 10.1111/j.1600-0897.2010.00844.x

Laškarin G, Redžovic A, Vukelić P, Veljković D, Gulić T, Haller H, and sur.. Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy. American Journal of Reproductive Immunology [Internet]. 2010 April [cited 2024 April 30];64:347-358. doi: 10.1111/j.1600-0897.2010.00844.x

G. Laškarin, et al., "Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy", American Journal of Reproductive Immunology, vol. 64, pp. 347-358, April 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:880108. [Accessed: 30 April 2024]

Metadata
Title (english)Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy
AuthorGordana Laškarin
AuthorArnela Redžovic
AuthorPetar Vukelić
AuthorDanijela Veljković
AuthorTamara Gulić
AuthorHerman Haller
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Phenotype of NK cells and cytotoxic/apoptotic mediators expression in ectopic pregnancy. Am J Reprod Immunol 2010 Problem The expression of cytotoxic/apoptotic mediators and the phenotype characteristics of uterine NK cells (uNK) in tubal ectopic pregnancy (EP) were investigated. Method of study Samples of uterine decidua and tubal mucosa as well as peripheral blood (PB) of the same women with EP were used for phenotype characterization of NK cells and detection of cytotoxic/apoptotic mediators and IL-15. Results In tubal mucosa, perforin, FasL, granulysin and IL-15 were almost completely absent, but they were present in normal and EP uterine deciduas. TRAIL was present on trophoblast and tubal mucosa, contrary to its lack in normal and EP uterine decidua. CD16-CD56dim NK cells, mostly CD94- and NKG2A-, predominate in tubal mucosa, whereas CD16-CD56bright NK cells, predominantly CD94+ and NKG2A+ prevail in EP uterine decidua. NK cells at the EP implantation site express lower percentages of perforin and granulysin, but they express a higher percentage of TRAIL than do EP uterine decidual and PB NK cells. Lower percentage of TNF-α-expressing and IL-4-expressing NK cells were found at the implantation site compared to EP uterine decidua. Conclusions Authentic uNK cell population seems to be insufficient to restrict trophoblast invasion because of low expression of cytotoxic/apoptotic mediators.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 64, pp. 347-358
p-ISSN1046-7408
e-ISSN1600-0897
DOIhttps://doi.org/10.1111/j.1600-0897.2010.00844.x
URN:NBNurn:nbn:hr:184:880108
Publication2010-04
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2010.00844.x
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-06-30 08:59:23