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master's thesis
Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom
diplomski rad
Rijeka: University of Rijeka, Faculty of Medicine, 2023. urn:nbn:hr:184:508389
Šimić, Iva
University of Rijeka
Faculty of Medicine
Department of Otorhinolaryngology

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Šimić, I. (2023). Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:508389

Šimić, Iva. "Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:508389

Šimić, Iva. "Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:508389

Šimić, I. (2023). 'Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 07 May 2024, https://urn.nsk.hr/urn:nbn:hr:184:508389

Šimić I. Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2023 [cited 2024 May 07] Available at: https://urn.nsk.hr/urn:nbn:hr:184:508389

I. Šimić, "Funkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:184:508389

Metadata
TitleFunkcionalni i onkološki ishodi bolesnika liječenih frontolateralnom laringektomijom : diplomski rad
Title (english)Functional and oncological outcomes of patients treated with frontolateral laryngectomy
AuthorIva Šimić
MentorDiana Maržić (mentor)
MentorBlažen Marijić (komentor)
Committee memberTamara Braut (predsjednik povjerenstva)
Committee memberMarko Velepič (član povjerenstva)
Committee memberIta Hadžisejdić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Rijeka
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract
Cilj rada: Analizirati i statistički obraditi funkcionalne i onkološke ishode bolesnika s ranim stadijem skvamoznog karcinoma grkljana tretiranih frontolateralnom laringektomijom. Ispitanici i metode: Retrospektivnim istraživanjem obuhvaćeno je 45 pacijenata, od čega su 3 bila ženskoga, a 42 muškoga spola. Akt gutanja, respiratorna i fonatorna funkcija su komponente na temelju kojih se procijenio funkcionalni ishod. Respiratorna funkcija se smatra urednom u slučaju nepostojanja stenoza te uspješnog dekanilmana. Pomoću anamneze i fiberlaringoskopskog pregleda procjenjivan je akt gutanja. Evaluacija glasa provodila se auditivno-perceptivnom procjenom (GRBAS skala), spektralnom akustičnom analizom kao objektivnom metodom, te subjektivnom procjenom glasa bolesnika pomoću VHI 30 upitnika (Voice Handicap Index 30). Kaplan-Meierovim krivuljama ukupnog preživljenja (overall survival), preživljenja bez bolesti (disease free survival) i preživljenja vezanog uz bolest (disease specific survival) prikazan je onkološki ishod. Rezultati: Svi bolesnici imali su tumor glotičkog dijela grkljana, te su bili svrstani u T1 (60 %) ili T2 (40 %) stadij bolesti. Zbog limfovaskularne invazije tumora ili R1 resekcijskih rubova, postoperativna radioterapija primijenjena je u 15 (33,3 %) bolesnika. U svih pacijenata uredno je izvršen dekanilman, te su svi imali urednu respiratornu funkciju. Nijednom bolesniku nije verificiran poremećaj gutanja. Rezultati evaluacije glasa ukazuju da bolesnici imaju umjerene vokalne poteškoće. Analiza onkološkog ishoda iznosi da je petogodišnje preživljenje vezano uz bolest 100 %, petogodišnje ukupno preživljenje 93,3 %, dok je petogodišnje preživljenje bez bolesti iznosilo 86,7 %. Lokalni recidiv bolesti razvio se u dva bolesnika, a regionalni u jednog. Zaključak: Frontolateralna laringektomija pruža odličan onkološki ishod, te treba biti alternativna metoda liječenja u odabranim slučajevima.
Abstract (english)
Objective: To analyze and statistically process the functional and oncological outcomes of patients with early stage squamous laryngeal carcinoma treated by frontolateral laryngectomy. Materials and methods: 45 patients were included in the retrospective study, 3 were female and 42 were male. The functional outcome was assessed based on respiratory and phonatory function, and the act of swallowing. Respiratory function is considered normal in the absence of stenosis and successful decannulation. The act of swallowing was assessed using the anamnesis and fiberlaryngoscopy examination. The evaluation of voice was carried out by auditory-perceptual evaluation (GRBAS scale), spectral acoustic analysis as an objective method, and subjective evaluation of the patient's voice using the VHI 30 questionnaire (Voice Handicap Index 30). Kaplan-Meier curves of overall survival, disease-free survival and disease-specific survival show the oncological outcome. Results: All patients had a tumor in the glottic region of the larynx, and were classified as T1 (60%) or T2 (40%) of the disease. Due to lymphovascular tumor invasion or R1 resection margins, postoperative radiotherapy was applied in 15 (33.3%) patients. Decannulation was properly performed in all patients, and all had normal respiratory function. A swallowing disorder wasn’t verified in any of the patients. The results of the voice evaluation indicate that the patients have moderate vocal difficulties. The analysis of the oncological outcome shows that the five-year survival related to the disease is 100%, the five-year overall survival is 93.3%, while the five-year survival without the disease was 86.7%. Local recurrence of the disease developed in 2 patients, and regional recurrence in one. Conclusion: Frontolateral laryngectomy provides an excellent oncological outcome, and should be an alternative method of treatment in selected cases.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:508389
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-03 15:18:42