Background: Difficult intubation represents a significant challenge that can lead to complications and unfavorable outcomes. Predicting difficult intubation is crucial in anesthesia practice to reduce risks and ensure patient safety. The Modified Mallampati and Cormack-Lehane classifications are commonly used to assess the likelihood of difficult laryngoscopy and intubation. Objectives: To compare the Mallampati and Cormack-Lehane classifications in predicting difficult intubation and to evaluate each classification individually as a predictor of difficult intubation. Participants and Methods: The study included 260 patients who underwent elective laparoscopic surgeries in the departments of gynecology and digestive surgery from January to March 2023 at Clinical Hospital Center Rijeka. General and specific data were retrospectively analyzed from patients' medical records. Results: Both classification systems showed lower sensitivity, indicating a higher percentage of false-negative results. However, the Cormack-Lehane classification demonstrated a specificity of 100 %, while Mallampati had a specificity of 80.32 %. There was no correlation between Mallampati classification and difficult intubation, while Cormack-Lehane classification showed a strong statistically significant association with difficult intubation. The results between Mallampati and Cormack-Lehane classifications revealed a statistically significant but weak correlation. Conclusion: The Cormack-Lehane classification exhibited a higher diagnostic value than the Mallampati classification in predicting difficult intubation. There is a positive, statistically significant correlation between the two analyzed classifications, but it lacks strength.