prikaz prve stranice dokumenta Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients
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Scientific paper - Original scientific paper
Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients
Prostaglandins, Leukotrienes and Essential Fatty Acids, 194 (2023); 102578. https://doi.org/10.1016/j.plefa.2023.102578
Nadalin, Sergej; Zatković, Lena; Peitl, Vjekoslav; Karlović, Dalibor; Vidrih, Branka; Puljić, Antonia; Pavlić, Sanja Dević; Buretić-Tomljanović, Alena

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Nadalin, S., Zatković, L., Peitl, V., Karlović, D., Vidrih, B., Puljić, A. ... Buretić Tomljanović, A. (2023). Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients. Prostaglandins, Leukotrienes and Essential Fatty Acids, 194.. doi: 10.1016/j.plefa.2023.102578

Nadalin, Sergej, et al. "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients." Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 194, 2023. https://doi.org/10.1016/j.plefa.2023.102578

Nadalin, Sergej, Lena Zatković, Vjekoslav Peitl, Dalibor Karlović, Branka Vidrih, Antonia Puljić, Sanja Dević Pavlić and Alena Buretić Tomljanović. "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients." Prostaglandins, Leukotrienes and Essential Fatty Acids 194 (2023). https://doi.org/10.1016/j.plefa.2023.102578

Nadalin, S., et al. (2023) 'Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients', Prostaglandins, Leukotrienes and Essential Fatty Acids, 194. doi: 10.1016/j.plefa.2023.102578

Nadalin S, Zatković L, Peitl V, Karlović D, Vidrih B, Puljić A, and sur.. Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients. Prostaglandins, Leukotrienes and Essential Fatty Acids [Internet]. 2023 July [cited 2024 November 23];194. doi: 10.1016/j.plefa.2023.102578

S. Nadalin, et al., "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients", Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 194, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:599392. [Accessed: 23 November 2024]

Metadata
Title (english)Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients
AuthorSergej Nadalin
AuthorLena Zatković
AuthorVjekoslav Peitl
AuthorDalibor Karlović
AuthorBranka Vidrih
AuthorAntonia Puljić
AuthorSanja Dević Pavlić
AuthorAlena Buretić-Tomljanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Here we investigated whether antipsychotic treatment was influenced by three polymorphisms: rs10798059 (BanI) in the phospholipase A2 (PLA2)G4A gene, rs4375 in PLA2G6, and rs1549637 in PLA2G4C. A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis/restriction fragment length polymorphism. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). We found that PLA2G4A polymorphism influenced changes in PANSS psychopathology, and PLA2G6 polymorphism influenced changes in PANSS psychopathology and metabolic parameters. PLA2G4C polymorphism did not show any impact on PANSS psychopathology or metabolic parameters. The polymorphisms’ effect sizes were estimated as moderate to strong, with contributions ranging from around 6.2–15.7%. Furthermore, the polymorphisms’ effects manifested in a gender-specific manner.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProstaglandins, Leukotrienes and Essential Fatty Acids
Numberingvol. 194, 102578
p-ISSN0952-3278
DOIhttps://doi.org/10.1016/j.plefa.2023.102578
URN:NBNurn:nbn:hr:184:599392
Publication2023-07
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0952327823000479
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-08-18 07:12:06