prikaz prve stranice dokumenta TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
  Download
PDF 8.27 MB
Scientific paper - Original scientific paper
TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
Nature Communications, 14 (2023), 1; 5016. https://doi.org/10.1038/s41467-023-40755-3
Worboys, Jonathan D.; Vowell, Katherine N.; Hare, Roseanna K.; Ambrose, Ashley R.; Bertuzzi, Margherita; Conner, Michael A.; Patel, Florence P.; Zammit, William H.; Gali-Moya, Judit; Hazime, Khodor S.; Jones, Katherine L.; Rey, Camille; Jonjić, Stipan; Roviš, Tihana Lenac; Tannahill, Gillian M.; Cruz De Matos, Gabriela Dos Santos; Waight, Jeremy D.; Davis, Daniel M. More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Worboys, J. D., Vowell, K. N., Hare, R. K., Ambrose, A. R., Bertuzzi, M., Conner, M. A. ... Davis, D. M. (2023). TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nature Communications, 14. (1). doi: 10.1038/s41467-023-40755-3

Worboys, Jonathan D., et al. "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation." Nature Communications, vol. 14, no. 1, 2023. https://doi.org/10.1038/s41467-023-40755-3

Worboys, Jonathan D., Katherine N. Vowell, Roseanna K. Hare, Ashley R. Ambrose, Margherita Bertuzzi, Michael A. Conner, Florence P. Patel, et al. "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation." Nature Communications 14, no. 1 (2023). https://doi.org/10.1038/s41467-023-40755-3

Worboys, J. D., et al. (2023) 'TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation', Nature Communications, 14(1). doi: 10.1038/s41467-023-40755-3

Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, and sur.. TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nature Communications [Internet]. 2023 August 18 [cited 2024 May 14];14(1). doi: 10.1038/s41467-023-40755-3

J. D. Worboys, et al., "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation", Nature Communications, vol. 14, no. 1, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:636511. [Accessed: 14 May 2024]

Metadata
Title (english)TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
AuthorJonathan D. Worboys
AuthorKatherine N. Vowell
AuthorRoseanna K. Hare
AuthorAshley R. Ambrose
AuthorMargherita Bertuzzi
AuthorMichael A. Conner
AuthorFlorence P. Patel
AuthorWilliam H. Zammit
AuthorJudit Gali-Moya
AuthorKhodor S. Hazime
AuthorKatherine L. Jones
AuthorCamille Rey
AuthorStipan Jonjić
AuthorTihana Lenac Roviš
AuthorGillian M. Tannahill
AuthorGabriela Dos Santos Cruz De Matos
AuthorJeremy D. Waight
AuthorDaniel M. Davis
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell intrinsic inhibitory signals in T cells remains unclear. Here we show, by ana lysing lymphocytes from matched human tumour and peripheral blood sam ples, that TIGIT and CD226 co-expression is rare on tumour-infiltrating lymphocytes. Using super-resolution microscopy and other techniques, we demonstrate that ligation with CD155 causes TIGIT to reorganise into dense nanoclusters, which coalesce with T cell receptor (TCR)-rich clusters at immune synapses. Functionally, this reduces cytokine secretion in a manner dependent on TIGIT’s intracellular ITT-like signalling motif. Thus, we provide evidence that TIGIT directly inhibits lymphocyte activation, acting indepen dently of CD226, requiring intracellular signalling that is proximal to the TCR. Within the subset of tumours where TIGIT-expressing cells do not commonly co-express CD226, this will likely be the dominant mechanism of action.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Communications
Numberingvol. 14, no. 1, 5016
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-40755-3
URN:NBNurn:nbn:hr:184:636511
Publication2023-08-18
Document URLhttps://www.nature.com/articles/s41467-023-40755-3
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-31 10:52:24