Title Celijakija
Title (english) Celiac disease
Author Vladimir Šupek
Mentor Božena Ćurko-Cofek (mentor)
Committee member Gordana Čanadi Jurešić (predsjednik povjerenstva)
Committee member Nada Starčević Čizmarević (član povjerenstva)
Granter University of Rijeka Faculty of Medicine (Department of Physiology, Immunology and Pathophxsiology) Rijeka
Defense date and country 2023-09-15, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Human Physiology
Abstract Celijakija je kronična autoimuna bolest tankog crijeva uzrokovana preosjetljivošću na gluten kao posljedica genetske podloge, promjene u sastavu crijevne mikrobiote i virusnih infekcija. Patogeneza bolesti je kompleksna jer dolazi do aktivacije mehanizama urođene i stečene imunosti što rezultira histološkim promjenama u obliku upale tankog crijeva, atrofije crijevnih resica i hiperplazije kripti što je praćeno pojavom kliničkih simptoma bolesti. Klinička slika je raznolika jer se bolest osim u gastrointestinalnom traktu može manifestirati i u drugim organskim sustavima te tako dovesti do težih posljedica. Gastrointestinalni simptomi koji se najčešće javljaju u oboljelih su proljev, nadutost, aftozni stomatitis, konstipacija, kronična abdominalna bol i povraćanje, dok se od ekstraintestinalnih simptoma često javljaju osteoporoza, anemija i Dermatitis herpetiformis. Učestalost bolesti u populaciji utvrđuje se serološkim pretragama i biopsijom tankog crijeva koja pokazuje stupanj oštećenja crijevnih resica. Dijagnoza celijakije postavlja se ukoliko je zadovoljeno 4 od 5 dijagnostičkih kriterija (klinički simptomi, serološki i genetički testovi, biopsija, odgovor na terapiju). Trenutno jedina dostupna terapija koja se koristi u liječenju osoba sa celijakijom je striktna bezglutenska dijeta što podrazumijeva izbjegavanje proizvoda koji sadrže gluten.
Abstract (english) Celiac disease is a chronic autoimmune disease of the small intestine caused by hypersensitivity to gluten because of the genetic basis of the disease, changes in the composition of the intestinal microbiota and viral infections. The pathogenesis of the disease is complex because the activated mechanisms of innate and acquired immunity result in histological changes in the form of inflammation of the small intestine, atrophy of intestinal villi and hyperplasia of the crypts, leading to the appearance of clinical symptoms of the disease. The clinical presentation is diverse because the disease can manifest itself in other organ systems besides the gastrointestinal tract, thus leading to more serious consequences. Gastrointestinal symptoms most often in patients are diarrhoea, flatulence, aphthous stomatitis, constipation, chronic abdominal pain and vomiting, while extraintestinal symptoms often include osteoporosis, anaemia and Dermatitis herpetiformis. The frequency of the disease in the population is determined by serological tests and small intestine biopsy, which shows the degree of intestinal villi damage. Celiac disease is diagnosed if 4 out of 5 criteria are met (clinical symptoms, serological and genetic tests, biopsy, response to therapy). Currently, the only available therapy used in the treatment of patients with celiac disease is a strict gluten-free diet, which means avoiding products containing gluten.
Keywords
Celijakija
Gluten
Imunološki odgovor
Bezglutenska prehrana
Keywords (english)
Celiac disease
Gluten
Immune response
Gluten-free diet
Language croatian
URN:NBN urn:nbn:hr:184:053539
Study programme Title: Study of Sanitary Engineering Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) sanitarnog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) sanitarnog inženjerstva)
Type of resource Text
File origin Born digital
Access conditions Open access
Terms of use
Created on 2023-09-11 08:07:03