prikaz prve stranice dokumenta First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin
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Scientific paper - Original scientific paper
First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin
American Journal of Reproductive Immunology, 66 (2011), 5; 363-372. https://doi.org/10.1111/j.1600-0897.2011.01015.x
Vujaklija, Danijela Veljković; Gulić, Tamara; Sucic, Sonja; Nagata, Kinya; Ogawa, Kazuyuki; Laškarin, Gordana; Saito, Shigeru; Haller, Herman; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Vujaklija, D. V., Gulić, T., Sucic, S., Nagata, K., Ogawa, K., Laškarin, G. ... Rukavina, D. (2011). First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin. American Journal of Reproductive Immunology, 66. (5), 363-372. doi: 10.1111/j.1600-0897.2011.01015.x

Vujaklija, Danijela Veljković, et al. "First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin." American Journal of Reproductive Immunology, vol. 66, no. 5, 2011, pp. 363-372. https://doi.org/10.1111/j.1600-0897.2011.01015.x

Vujaklija, Danijela Veljković, Tamara Gulić, Sonja Sucic, Kinya Nagata, Kazuyuki Ogawa, Gordana Laškarin, Shigeru Saito, Herman Haller and Daniel Rukavina. "First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin." American Journal of Reproductive Immunology 66, no. 5 (2011): 363-372. https://doi.org/10.1111/j.1600-0897.2011.01015.x

Vujaklija, D. V., et al. (2011) 'First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin', American Journal of Reproductive Immunology, 66(5), pp. 363-372. doi: 10.1111/j.1600-0897.2011.01015.x

Vujaklija DV, Gulić T, Sucic S, Nagata K, Ogawa K, Laškarin G, and sur.. First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin. American Journal of Reproductive Immunology [Internet]. 2011 November [cited 2024 April 30];66(5):363-372. doi: 10.1111/j.1600-0897.2011.01015.x

D. V. Vujaklija, et al., "First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin", American Journal of Reproductive Immunology, vol. 66, no. 5, pp. 363-372, November 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:738684. [Accessed: 30 April 2024]

Metadata
Title (english)First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin
AuthorDanijela Veljković Vujaklija
AuthorTamara Gulić
AuthorSonja Sucic
AuthorKinya Nagata
AuthorKazuyuki Ogawa
AuthorGordana Laškarin
AuthorShigeru Saito
AuthorHerman Haller
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
Problem Granulysin (GNLY) is a novel cytolytic protein lytic against a variety of tumor cells and microbes. The role of GNLY during pregnancy has not been extensively explored. The aim of this study is to examine GNLY expression and distribution in the first trimester pregnancy peripheral blood (PB) and decidua, the ability of decidual and PB natural killer (NK) cells to secrete GNLY spontaneously, and the role of antigen-presenting cells (APC) in the regulation of GNLY expression in decidual NK cells. Method of study GNLY expression was analyzed using cell permeabilization method, flow cytometry, and immunohistochemistry. GNLY secretion by purified NK cells was detected by ELISA method. Results GNLY is abundantly expressed at the maternal–fetal interface in the first trimester pregnancy. Decidual T lymphocytes express significantly higher levels of GNLY (58%) then PB T lymphocytes (11%). Over 85% of decidual CD56+ cells express GNLY and when cultured spontaneously release high quantities of GNLY. Decidual APC participate in the control of GNLY expression in CD56+ cells. Conclusion Abundant expression of GNLY in the decidual immunocompetent cells and the capacity of decidual CD56+ cells to spontaneously secrete high quantities of GNLY point to important protective and immunomodulatory role that this molecule could play at the maternal–fetal interfac
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 66, no. 5, pp. 363-372
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/j.1600-0897.2011.01015.x
URN:NBNurn:nbn:hr:184:738684
Publication2011-11
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2011.01015.x
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-09-18 10:28:39