prikaz prve stranice dokumenta Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness
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Scientific paper - Original scientific paper
Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness
Frontiers in Immunology, 14 (2023); 1191884. https://doi.org/10.3389/fimmu.2023.1191884
Imširović, Vanna; Lenartić, Maja; Wensveen, Felix M.; Polić, Bojan; Jelenčić, Vedrana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Imširović, V., Lenartić, M., Wensveen, F. M., Polić, B. & Jelenčić, V. (2023). Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness. Frontiers in Immunology, 14.. doi: 10.3389/fimmu.2023.1191884

Imširović, Vanna, et al. "Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness." Frontiers in Immunology, vol. 14, 2023. https://doi.org/10.3389/fimmu.2023.1191884

Imširović, Vanna, Maja Lenartić, Felix M. Wensveen, Bojan Polić and Vedrana Jelenčić. "Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness." Frontiers in Immunology 14 (2023). https://doi.org/10.3389/fimmu.2023.1191884

Imširović, V., et al. (2023) 'Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness', Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1191884

Imširović V, Lenartić M, Wensveen FM, Polić B, Jelenčić V. Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness. Frontiers in Immunology [Internet]. 2023 [cited 2024 May 18];14. doi: 10.3389/fimmu.2023.1191884

V. Imširović, M. Lenartić, F. M. Wensveen, B. Polić and V. Jelenčić, "Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness", Frontiers in Immunology, vol. 14, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:744755. [Accessed: 18 May 2024]

Metadata
Title (english)Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness
AuthorVanna Imširović
AuthorMaja Lenartić
AuthorFelix M. Wensveen
AuthorBojan Polić
AuthorVedrana Jelenčić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells play an important role in the early defense against tumors and virally infected cells. Their function is thought to be controlled by the balance between activating and inhibitory receptors, which often compete for the same ligands. Several activating receptors expressed on virtually all NK cells lack an inhibitory partner, most notably CD16, NCR1 and NKG2D. We therefore hypothesized that a signal through at least one of these receptors is always required for full NK cell activation. We generated animals lacking all three receptors (TKO) and analyzed their NK cells. , TKO NK cells did not show reduced ability to kill tumor targets but displayed hyperresponsiveness to NK1.1 stimulation. , TKO animals had a minor reduction in their ability to control non-hematopoietic tumors and cytomegalovirus infection, which was the result of reduced NK cell activity. Together, our findings show that activating NK cell receptors without an inhibitory partner do not provide a ‘master’ signal but are integrated in the cumulative balance of activating and inhibitory signals. Their activity is controlled through regulation of the responsiveness and expression of other activating receptors. Our findings may be important for future development of NK cell-based cancer immunotherapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Immunology
Numberingvol. 14, 1191884
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2023.1191884
URN:NBNurn:nbn:hr:184:744755
Publication2023
ProjectNumber: KK.011.1.01.0006
Title (english): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1191884/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-10-10 13:38:10