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Scientific paper - Original scientific paper
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
Nature Communications, 14 (2023), 1; 1-17. https://doi.org/10.1038/s41467-023-42182-w
Rožmanić, Carmen; Lisnić, Berislav; Pribanić Matešić, Marina; Mihalić, Andrea; Hiršl, Lea; Park, Eugene; Lesac Brizić, Ana; Indenbirken, Daniela; Viduka, Ina; Šantić, Marina; Adler, Barbara; Yokoyama, Wayne M.; Krmpotić, Astrid; Juranić Lisnić, Vanda; Jonjić, Stipan; Brizić, Ilija More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Rožmanić, C., Lisnić, B., Pribanić Matešić, M., Mihalić, A., Hiršl, L., Park, E. ... Brizić, I. (2023). Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nature Communications, 14. (1), 1-17. doi: 10.1038/s41467-023-42182-w

Rožmanić, Carmen, et al. "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells." Nature Communications, vol. 14, no. 1, 2023, pp. 1-17. https://doi.org/10.1038/s41467-023-42182-w

Rožmanić, Carmen, Berislav Lisnić, Marina Pribanić Matešić, Andrea Mihalić, Lea Hiršl, Eugene Park, Ana Lesac Brizić, et al. "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells." Nature Communications 14, no. 1 (2023): 1-17. https://doi.org/10.1038/s41467-023-42182-w

Rožmanić, C., et al. (2023) 'Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells', Nature Communications, 14(1), pp. 1-17. doi: 10.1038/s41467-023-42182-w

Rožmanić C, Lisnić B, Pribanić Matešić M, Mihalić A, Hiršl L, Park E, and sur.. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nature Communications [Internet]. 2023 October 12 [cited 2024 May 14];14(1):1-17. doi: 10.1038/s41467-023-42182-w

C. Rožmanić, et al., "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells", Nature Communications, vol. 14, no. 1, pp. 1-17, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:168696. [Accessed: 14 May 2024]

Metadata
Title (english)Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
AuthorCarmen Rožmanić
AuthorBerislav Lisnić
AuthorMarina Pribanić Matešić
AuthorAndrea Mihalić
AuthorLea Hiršl
AuthorEugene Park
AuthorAna Lesac Brizić
AuthorDaniela Indenbirken
AuthorIna Viduka
AuthorMarina Šantić
AuthorBarbara Adler
AuthorWayne M. Yokoyama
AuthorAstrid Krmpotić
AuthorVanda Juranić Lisnić
AuthorStipan Jonjić
AuthorIlija Brizić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Infections in early life can elicit substantially different immune responses and pathogenesis than infections in adulthood. Here, we investigate the consequences of murine cytomegalovirus infection in newborn mice on NK cells. We show that infection severely compromised NK cell maturation and functionality in newborns. This effect was not due to compromised virus control. Inflammatory responses to infection dysregulated the expression of major transcription factors governing NK cell fate, such as Eomes, resulting in impaired NK cell function. Most prominently, NK cells from perinatally infected mice have a diminished ability to produce IFN-γ due to the downregulation of long non-coding RNA Ifng-as1 expression. Moreover, the bone marrow's capacity to efficiently generate new NK cells is reduced, explaining the prolonged negative effects of perinatal infection on NK cells. This study demonstrates that viral infections in early life can profoundly impact NK cell biology, including long-lasting impairment in NK cell functionality.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Communications
Numberingvol. 14, no. 1, pp. 1-17, 6412
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-42182-w
URN:NBNurn:nbn:hr:184:168696
Publication2023-10-12
ProjectNumber: IP-2018-01-4435
Title (croatian): NK stanice u patogenezi kongenitalne infekcije citomegalovirusom
Acronym: NKconCMV
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: Nema
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttps://www.nature.com/articles/s41467-023-42182-w
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-10-17 11:54:35