prikaz prve stranice dokumenta NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
No public access
Scientific paper - Original scientific paper
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
Science Immunology, 8 (2023), 87; 1599. https://doi.org/10.1126/sciimmunol.add1599
Marinović, Sonja; Lenartić, Maja; Mladenić, Karlo; Šestan, Marko; Kavazović, Inga; Benić, Ante; Krapić, Mia; Rindlisbacher, Lukas; Cokarić Brdovčak, Maja; Sparano, Colin; Litscher, Gioana; Turk Wensveen, Tamara; Mikolašević, Ivana; Fučkar Čupić, Dora; Bilić-Zulle, Lidija; Steinle, Aleksander; Waisman, Ari; Hayday, Adrian; Tugues, Sonia; Becher, Burkhard; Polić, Bojan; Wensveen, Felix M More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Marinović, S., Lenartić, M., Mladenić, K., Šestan, M., Kavazović, I., Benić, A. ... Wensveen, F. M. (2023). NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.. Science Immunology, 8. (87), 1599. doi: 10.1126/sciimmunol.add1599

Marinović, Sonja, et al. "NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.." Science Immunology, vol. 8, no. 87, 2023, p. 1599. https://doi.org/10.1126/sciimmunol.add1599

Marinović, Sonja, Maja Lenartić, Karlo Mladenić, Marko Šestan, Inga Kavazović, Ante Benić, Mia Krapić, et al. "NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.." Science Immunology 8, no. 87 (2023): 1599. https://doi.org/10.1126/sciimmunol.add1599

Marinović, S., et al. (2023) 'NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.', Science Immunology, 8(87), p. 1599. doi: 10.1126/sciimmunol.add1599

Marinović S, Lenartić M, Mladenić K, Šestan M, Kavazović I, Benić A, and sur.. NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.. Science Immunology [Internet]. 2023 September 29 [cited 2024 November 26];8(87):1599. doi: 10.1126/sciimmunol.add1599

S. Marinović, et al., "NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.", Science Immunology, vol. 8, no. 87, p. 1599, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:878394. [Accessed: 26 November 2024]

Metadata
Title (english)NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
AuthorSonja Marinović
AuthorMaja Lenartić
AuthorKarlo Mladenić
AuthorMarko Šestan
AuthorInga Kavazović
AuthorAnte Benić
AuthorMia Krapić
AuthorLukas Rindlisbacher
AuthorMaja Cokarić Brdovčak
AuthorColin Sparano
AuthorGioana Litscher
AuthorTamara Turk Wensveen
AuthorIvana Mikolašević
AuthorDora Fučkar Čupić
AuthorLidija Bilić-Zulle
AuthorAleksander Steinle
AuthorAri Waisman
AuthorAdrian Hayday
AuthorSonia Tugues
AuthorBurkhard Becher
AuthorBojan Polić
AuthorFelix M Wensveen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations ranging from benign steatosis to cirrhosis. A key event in the pathophysiology of MAFLD is the development of nonalcoholic steatohepatitis (NASH), which can potentially lead to fibrosis and hepatocellular carcinoma, but the triggers of MAFLDassociated inflammation are not well understood. We have observed that lipid accumulation in hepatocytes induces expression of ligands specific to the activating immune receptor NKG2D. Tissue-resident innate-like T cells, most notably γδ T cells, are activated through NKG2D and secrete IL-17A. IL-17A licenses hepatocytes to produce chemokines that recruit proinflammatory cells into the liver, which causes NASH and fibrosis. NKG2D-deficient mice did not develop fibrosis in dietary models of NASH and had a decreased incidence of hepatic tumors. The frequency of IL-17A+ γδ T cells in the blood of patients with MAFLD correlated directly with liver pathology. Our findings identify a key molecular mechanism through which stressed hepatocytes trigger inflammation in the context of MAFLD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScience Immunology
Numberingvol. 8, no. 87, p. 1599, 1
BPC3000 USD
p-ISSN2470-9468
DOIhttps://doi.org/10.1126/sciimmunol.add1599
URN:NBNurn:nbn:hr:184:878394
Publication2023-09-29
ProjectNumber: IP-2016-06-9306
Title (croatian): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Title (english): Immune mechanisms in development of inflammation and metabolic syndrome in obesity
Acronym: INFLAMETAB
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Title (english): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Acronym: T-MEMORY
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-CORONA-2020-04-2045
Title (croatian): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Title (english): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Acronym: CORONAWAI
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP-CORONA
ProjectNumber: IP-2020-02-7928
Title (croatian): Utjecaj šećerne bolesti tipa 2 i njezinog liječenja na funkciju limfocita
Acronym: DIABOLYC
Leader: Tamara Turk Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://www.science.org/doi/10.1126/sciimmunol.add1599?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-10-23 10:28:10