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Scientific paper - Review paper
Innate Immunity in Autoimmune Thyroid Disease during Pregnancy
International Journal of Molecular Sciences, 24 (2023), 20; 15442. https://doi.org/10.3390/ijms242015442
Bogović Crnčić, Tatjana; Girotto, Neva; Ilić Tomaš, Maja; Krištofić, Ines; Klobučar, Sanja; Batičić, Lara; Ćurko-Cofek, Božena; Sotošek, Vlatka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bogović Crnčić, T., Girotto, N., Ilić Tomaš, M., Krištofić, I., Klobučar, S., Batičić, L. ... Sotošek, V. (2023). Innate Immunity in Autoimmune Thyroid Disease during Pregnancy. International Journal of Molecular Sciences, 24. (20). doi: 10.3390/ijms242015442

Bogović Crnčić, Tatjana, et al. "Innate Immunity in Autoimmune Thyroid Disease during Pregnancy." International Journal of Molecular Sciences, vol. 24, no. 20, 2023. https://doi.org/10.3390/ijms242015442

Bogović Crnčić, Tatjana, Neva Girotto, Maja Ilić Tomaš, Ines Krištofić, Sanja Klobučar, Lara Batičić, Božena Ćurko Cofek and Vlatka Sotošek. "Innate Immunity in Autoimmune Thyroid Disease during Pregnancy." International Journal of Molecular Sciences 24, no. 20 (2023). https://doi.org/10.3390/ijms242015442

Bogović Crnčić, T., et al. (2023) 'Innate Immunity in Autoimmune Thyroid Disease during Pregnancy', International Journal of Molecular Sciences, 24(20). doi: 10.3390/ijms242015442

Bogović Crnčić T, Girotto N, Ilić Tomaš M, Krištofić I, Klobučar S, Batičić L, and sur.. Innate Immunity in Autoimmune Thyroid Disease during Pregnancy. International Journal of Molecular Sciences [Internet]. 2023 October 22 [cited 2024 May 03];24(20). doi: 10.3390/ijms242015442

T. Bogović Crnčić, et al., "Innate Immunity in Autoimmune Thyroid Disease during Pregnancy", International Journal of Molecular Sciences, vol. 24, no. 20, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:295340. [Accessed: 03 May 2024]

Metadata
Title (english)Innate Immunity in Autoimmune Thyroid Disease during Pregnancy
AuthorTatjana Bogović Crnčić
AuthorNeva Girotto
AuthorMaja Ilić Tomaš
AuthorInes Krištofić
AuthorSanja Klobučar
AuthorLara Batičić
AuthorBožena Ćurko-Cofek
AuthorVlatka Sotošek
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder clinically presented as Hashimoto thyroiditis (HT) and Graves’ disease (GD). The pathogenesis of AITD is caused by an inappropriate immune response related to genetic, non-genetic, and environmental factors. Pregnancy is one of the factors that have a great influence on the function of the thyroid gland because of the increased metabolic demand and the effects of hormones related to pregnancy. During pregnancy, an adaptation of the maternal immune system occurs, especially of the innate immune system engaged in maintaining adaptive immunity in the tolerant state, preventing the rejection of the fetus. Pregnancy-related hormonal changes (estrogen, progesterone, hCG) may modulate the activity of innate immune cells, potentially worsening the course of AITD during pregnancy. This especially applies to NK cells, which are associated with exacerbation of HD and GD. On the other hand, previous thyroid disorders can affect fertility and cause adverse outcomes of pregnancy, such as placental abruption, spontaneous abortion, and premature delivery. Additionally, it can cause fetal growth retardation and may contribute to impaired neuropsychological development of the fetus. Therefore, maintaining the thyroid equilibrium in women of reproductive age and in pregnant women is of the highest importance.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 20, 15442
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms242015442
URN:NBNurn:nbn:hr:184:295340
Publication2023-10-22
Document URLhttps://www.mdpi.com/1422-0067/24/20/15442
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-10-25 08:17:08