prikaz prve stranice dokumenta Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection
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Scientific paper - Preliminary note / Short communication
Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection
Periodicum biologorum, 115 (2013), 2; 231-233. urn:nbn:hr:184:739688
Golubović, Snježana; Golubović, Vesna; Šutić, Ivana; Pavišić, Valentino; Šustić, Alan; Mrakovčić-Šutić, Ines

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Golubović, S., Golubović, V., Šutić, I., Pavišić, V., Šustić, A. & Mrakovčić Šutić, I. (2013). Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection. Periodicum biologorum, 115. (2), 231-233. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:739688

Golubović, Snježana, et al. "Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection." Periodicum biologorum, vol. 115, no. 2, 2013, pp. 231-233. https://urn.nsk.hr/urn:nbn:hr:184:739688

Golubović, Snježana, Vesna Golubović, Ivana Šutić, Valentino Pavišić, Alan Šustić and Ines Mrakovčić Šutić. "Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection." Periodicum biologorum 115, no. 2 (2013): 231-233. https://urn.nsk.hr/urn:nbn:hr:184:739688

Golubović, S., et al. (2013) 'Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection', Periodicum biologorum, 115(2), pp. 231-233. Available at: https://urn.nsk.hr/urn:nbn:hr:184:739688 (Accessed 27 December 2024)

Golubović S, Golubović V, Šutić I, Pavišić V, Šustić A, Mrakovčić Šutić I. Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection. Periodicum biologorum [Internet]. 2013 [cited 2024 December 27];115(2):231-233. Available at: https://urn.nsk.hr/urn:nbn:hr:184:739688

S. Golubović, V. Golubović, I. Šutić, V. Pavišić, A. Šustić and I. Mrakovčić Šutić, "Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection", Periodicum biologorum, vol. 115, no. 2, pp. 231-233, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:739688. [Accessed: 27 December 2024]

Metadata
Title (english)Early immunological events in postoperative epidural/intravenous analgesia after colorectal cancer resection
AuthorSnježana Golubović
AuthorVesna Golubović
AuthorIvana Šutić
AuthorValentino Pavišić
AuthorAlan Šustić
AuthorInes Mrakovčić-Šutić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract (english)
Background and purpose: Postoperative pain is a common consequence of extensive surgery with activation of the nervous system for the implementation of pain (nociceptive system), tissue injury or inflammation. As a result of tissue injury, many different mediators are released from damaged tissues, immunocompetent cells, sympathetic and sensory fibers which directly or indirectly activate nociceptors. Postoperative pain leads to suppression of the immune system, including reduced activity of NK cells, cytotoxic T lymphocytes and macrophages. Patients and Methods: We examined the effects of epidural and intravenous analgesia in patients after colorectal cancer surgery on the immune system. We analyzed the phenotype of isolated peripheral blood mononuclear cells of patients during first six postoperative days by flow cytometry and compared them with healthy volunteers. Results: Application of intravenous analgesia leads to statistically significant decreasing in the percentage of cells of innate immunity in comparison with them after epidural analgesia. Intravenous analgesia has led to a statistically significant reduction of subpopulation of T lymphocytes (CD3+) and B lymphocytes (CD19+) on the 6th postoperative day compared to epidural analgesia. Conclusion: Intravenous analgesia after colorectal cancer surgery has led to a statistically significant greater depression of innate and acquired immunity in comparison to epidural analgesia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePeriodicum biologorum
Numberingvol. 115, no. 2, pp. 231-233
p-ISSN0031-5362
e-ISSN1849-0964
URN:NBNurn:nbn:hr:184:739688
Publication2013
Document URLhttps://hrcak.srce.hr/105987
Type of resourceText
Access conditionsOpen access
Created on2023-11-02 09:29:09