prikaz prve stranice dokumenta Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients
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Scientific paper - Original scientific paper
Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients
Injury, 43 (2012), 5; 624-631. https://doi.org/10.1016/j.injury.2010.05.009
Sotošek Tokmadžic, Vlatka; Laškarin, Gordana; Mahmutefendic, Hana; Lučin, Pero; Mrakovčić-Šutic, Ines; Župan, Željko; Šustić, Alan

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Sotošek Tokmadžic, V., Laškarin, G., Mahmutefendic, H., Lučin, P., Mrakovčić Šutic, I., Župan, Ž. & Šustić, A. (2012). Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients. Injury, 43. (5), 624-631. doi: 10.1016/j.injury.2010.05.009

Sotošek Tokmadžic, Vlatka, et al. "Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients." Injury, vol. 43, no. 5, 2012, pp. 624-631. https://doi.org/10.1016/j.injury.2010.05.009

Sotošek Tokmadžic, Vlatka, Gordana Laškarin, Hana Mahmutefendic, Pero Lučin, Ines Mrakovčić Šutic, Željko Župan and Alan Šustić. "Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients." Injury 43, no. 5 (2012): 624-631. https://doi.org/10.1016/j.injury.2010.05.009

Sotošek Tokmadžic, V., et al. (2012) 'Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients', Injury, 43(5), pp. 624-631. doi: 10.1016/j.injury.2010.05.009

Sotošek Tokmadžic V, Laškarin G, Mahmutefendic H, Lučin P, Mrakovčić Šutic I, Župan Ž, and sur.. Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients. Injury [Internet]. 2012 [cited 2024 December 27];43(5):624-631. doi: 10.1016/j.injury.2010.05.009

V. Sotošek Tokmadžic, et al., "Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients", Injury, vol. 43, no. 5, pp. 624-631, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:153525. [Accessed: 27 December 2024]

Metadata
Title (english)Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients
AuthorVlatka Sotošek Tokmadžic
AuthorGordana Laškarin
AuthorHana Mahmutefendic
AuthorPero Lučin
AuthorInes Mrakovčić-Šutic
AuthorŽeljko Župan
AuthorAlan Šustić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
Purpose: The purpose of this study was to investigate the changes of cytotoxic protein-perforin in peripheral blood lymphocytes in severe TBI patients and possible correlation between severity of TBI and perforin expression. Methods: Flow cytometry was used for simultaneous detection of intracellular perforin and cell surface antigens of peripheral blood lymphocytes of 20 severe TBI patients on day 1, 4 and 7 after the onset of injury. Peripheral blood mononuclear cells from 20 healthy volunteers were used as control. Clinical and laboratory parameters were also recorded. Results: There was a statistically significant decrease of perforin-positive lymphocytes including T, natural killer (NK) and NKT cells on day 4 as compared with day 1 after the brain injury or healthy controls. On day 7, perforin expression was restored in lymphocyte of cytotoxic phenotype (CD8 + T lymphocytes, NK cells, and NKT cells) compared with day 1. High positive correlation was found between the severity of TBI and frequency of perforin-positive cells on day 4 when the occurrence of the intra-hospital infections was the highest. Conclusion: Severe TBI significantly decreases perforin expression in T lymphocytes, NK and NKT cells, which indicate a possible mechanism underlying the high susceptibility to infections. © 2010 Elsevier Ltd. All rights reserved.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInjury
Numberingvol. 43, no. 5, pp. 624-631
p-ISSN0020-1383
DOIhttps://doi.org/10.1016/j.injury.2010.05.009
URN:NBNurn:nbn:hr:184:153525
Publication2012
ProjectNumber: 062-0000000-0220
Title (croatian): Perkutana traheostomija u prevenciji pneumonije u strojno ventiliranih bolesnika
Title (english): Percutaneous tracheostomy in prevention of ventilator-associated pneumonia
Leader: Alan Šustić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0020138310002895
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-11-02 10:18:21