prikaz prve stranice dokumenta Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity
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Scientific paper - Original scientific paper
Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity
Rheumatology International, 43 (2023), 11; 2073-2079. https://doi.org/10.1007/s00296-023-05391-6
Šegota, Adelmo; Schnurrer-Luke-Vrbanić, Tea; Avancini-Dobrović, Viviana; Mirić, Filip

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Šegota, A., Schnurrer Luke Vrbanić, T., Avancini Dobrović, V. & Mirić, F. (2023). Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity. Rheumatology International, 43. (11), 2073-2079. doi: 10.1007/s00296-023-05391-6

Šegota, Adelmo, et al. "Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity." Rheumatology International, vol. 43, no. 11, 2023, pp. 2073-2079. https://doi.org/10.1007/s00296-023-05391-6

Šegota, Adelmo, Tea Schnurrer Luke Vrbanić, Viviana Avancini Dobrović and Filip Mirić. "Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity." Rheumatology International 43, no. 11 (2023): 2073-2079. https://doi.org/10.1007/s00296-023-05391-6

Šegota, A., et al. (2023) 'Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity', Rheumatology International, 43(11), pp. 2073-2079. doi: 10.1007/s00296-023-05391-6

Šegota A, Schnurrer Luke Vrbanić T, Avancini Dobrović V, Mirić F. Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity. Rheumatology International [Internet]. 2023 July 14 [cited 2024 May 08];43(11):2073-2079. doi: 10.1007/s00296-023-05391-6

A. Šegota, T. Schnurrer Luke Vrbanić, V. Avancini Dobrović and F. Mirić, "Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity", Rheumatology International, vol. 43, no. 11, pp. 2073-2079, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:632052. [Accessed: 08 May 2024]

Metadata
Title (english)Clinical significance of possible HLA biomarkers in axial spondyloarthritis beyond HLA-B27 positivity
AuthorAdelmo Šegota
AuthorTea Schnurrer-Luke-Vrbanić
AuthorViviana Avancini-Dobrović
AuthorFilip Mirić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Physical Medicine and Rehabilitation
Abstract (english)
The aim of this study is to compare four forms of axial spondyloarthritis (axSpA): non-radiographic axial spondyloarthritis (nr-axSpA), ankylosing spondylitis (AS), non-radiographic axial psoriatic arthritis (nr-axPsA) and radiographic axial psoriatic arthritis (r-axPsA). In a cross-sectional retrospective study, gender difference, human leukocyte antigen (HLA) typing, laboratory C-reactive protein (CRP) and erythrocyte sedimentation (SE) values, and radiographic and magnetic resonance scans were analyzed. One hundred and thirty-seven patients were included in the study: 45 AS, 51 nr-axSpA, 32 r-axPsA and 9 nr-axPsA; 74 women and 63 men. Most of the gender, laboratory and radiological findings confirmed the results of previously conducted studies about each group of the investigated axSpA. The key findings of our study are the newly detected findings of HLA typing beyond HLA-27 positivity: HLA-DR16 in AS, HLA-DR11 in nr-axSpA, HLA-B13, HLA-B57, HLA-Cw12 and HLA-DR7 in r-axPsA, and HLA-B18 in nr-axPsA. Our study also confirmed some of the results of previously conducted studies on predominant genes of HLA typing in axSpA: HLA-B27 in AS, HLA-B39 and HLA-Cw6 in r-axPsA, and HLA-Cw7 in nr-axPsA. Important conclusions about the nr-axPsA group cannot be drawn because of the very small number of subjects included in this group of axSpA. Our results suggest that the newly detected HLA typing findings beyond HLA-B27 positivity could be possible biomarkers of early detection of axSpA, but further studies on larger samples are needed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleRheumatology International
Numberingvol. 43, no. 11, pp. 2073-2079
e-ISSN1437-160X
DOIhttps://doi.org/10.1007/s00296-023-05391-6
URN:NBNurn:nbn:hr:184:632052
Publication2023-07-14
Document URLhttps://link.springer.com/10.1007/s00296-023-05391-6
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-11-10 09:59:33