prikaz prve stranice dokumenta Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations
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Scientific paper - Original scientific paper
Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations
Pharmaceuticals, 16 (2023), 10; 1489. https://doi.org/10.3390/ph16101489
Filošević Vujnović, Ana; Saftić Martinović, Lara; Medija, Marta; Andretić Waldowski, Rozi

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Filošević Vujnović, A., Saftić Martinović, L., Medija, M. & Andretić Waldowski, R. (2023). Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations. Pharmaceuticals, 16. (10). doi: 10.3390/ph16101489

Filošević Vujnović, Ana, et al. "Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations." Pharmaceuticals, vol. 16, no. 10, 2023. https://doi.org/10.3390/ph16101489

Filošević Vujnović, Ana, Lara Saftić Martinović, Marta Medija and Rozi Andretić Waldowski. "Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations." Pharmaceuticals 16, no. 10 (2023). https://doi.org/10.3390/ph16101489

Filošević Vujnović, A., et al. (2023) 'Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations', Pharmaceuticals, 16(10). doi: 10.3390/ph16101489

Filošević Vujnović A, Saftić Martinović L, Medija M, Andretić Waldowski R. Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations. Pharmaceuticals [Internet]. 2023 October 19 [cited 2024 December 23];16(10). doi: 10.3390/ph16101489

A. Filošević Vujnović, L. Saftić Martinović, M. Medija and R. Andretić Waldowski, "Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations", Pharmaceuticals, vol. 16, no. 10, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:625006. [Accessed: 23 December 2024]

Metadata
Title (english)Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in Drosophila melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations
AuthorAna Filošević Vujnović
AuthorLara Saftić Martinović
AuthorMarta Medija
AuthorRozi Andretić Waldowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Due to similarities in genetics, cellular response, and behavior, Drosophila is used as a model organism in addiction research. A well-described behavioral response examined in flies is the induced increase in locomotor activity after a single dose of volatilized cocaine (vCOC) and volatilized methamphetamine (vMETH), the sensitivity, and the escalation of the locomotor response after the repeated dose, the locomotor sensitization. However, knowledge about how vCOC and vMETH affect different neurotransmitter systems over time is scarce. We used LC-MS/MS to systematically examine changes in the concentration of neurotransmitters, metabolites and non-metabolized COC and METH in the whole head homogenates of male flies one to seven hours after single and double vCOC or vMETH administrations. vMETH leads to complex changes in the levels of examined substances over time, while vCOC strongly and briefly increases concentrations of dopamine, tyramine and octopamine followed by a delayed degradation into N-acetyl dopamine and N-acetyl tyramine. The first exposure to psychostimulants leads to significant and dynamic changes in the concentrations relative to the second administration when they are more stable over several hours. Further investigations are needed to understand neurochemical and molecular changes post-psychostimulant administration.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePharmaceuticals
Numberingvol. 16, no. 10, 1489
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16101489
URN:NBNurn:nbn:hr:184:625006
Publication2023-10-19
Document URLhttps://www.mdpi.com/1424-8247/16/10/1489
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-11-13 09:24:56