prikaz prve stranice dokumenta HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
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Scientific paper - Original scientific paper
HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
Journal of Virology, 97 (2023), 10; 1-21. https://doi.org/10.1128/jvi.00730-23
Zubković, Andreja; Gomes, Cristina; Parchure, Adwait; Cesarec, Mia; Ferenčić, Antun; Rokić, Filip; Jakovac, Hrvoje; Whitford, Abigail L.; Dochnal, Sara A.; Cliffe, Anna R.; Cuculić, Dražen; Gallo, Angela; Vugrek, Oliver; Hackenberg, Michael; Jurak, Igor More authors...

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Zubković, A., Gomes, C., Parchure, A., Cesarec, M., Ferenčić, A., Rokić, F. ... Jurak, I. (2023). HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia. Journal of Virology, 97. (10), 1-21. doi: 10.1128/jvi.00730-23

Zubković, Andreja, et al. "HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia." Journal of Virology, vol. 97, no. 10, 2023, pp. 1-21. https://doi.org/10.1128/jvi.00730-23

Zubković, Andreja, Cristina Gomes, Adwait Parchure, Mia Cesarec, Antun Ferenčić, Filip Rokić, Hrvoje Jakovac, et al. "HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia." Journal of Virology 97, no. 10 (2023): 1-21. https://doi.org/10.1128/jvi.00730-23

Zubković, A., et al. (2023) 'HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia', Journal of Virology, 97(10), pp. 1-21. doi: 10.1128/jvi.00730-23

Zubković A, Gomes C, Parchure A, Cesarec M, Ferenčić A, Rokić F, and sur.. HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia. Journal of Virology [Internet]. 2023 October 31 [cited 2024 November 23];97(10):1-21. doi: 10.1128/jvi.00730-23

A. Zubković, et al., "HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia", Journal of Virology, vol. 97, no. 10, pp. 1-21, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:705761. [Accessed: 23 November 2024]

Metadata
Title (english)HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
AuthorAndreja Zubković
AuthorCristina Gomes
AuthorAdwait Parchure
AuthorMia Cesarec
AuthorAntun Ferenčić
AuthorFilip Rokić
AuthorHrvoje Jakovac
AuthorAbigail L. Whitford
AuthorSara A. Dochnal
AuthorAnna R. Cliffe
AuthorDražen Cuculić
AuthorAngela Gallo
AuthorOliver Vugrek
AuthorMichael Hackenberg
AuthorIgor Jurak
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Forensic Medicine and Criminalistics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Herpes simplex virus 1 is an important human pathogen that has been intensively studied for many decades. Nevertheless, the molecular mechanisms regulating its establishment, maintenance, and reactivation from latency are poorly understood. Here, we show that HSV-1-encoded miR-H2 is post-transcriptionally edited in latently infected human tissues. Hyperediting of viral miRNAs increases the targeting potential of these miRNAs and may play an important role in regulating latency. We show that the edited miR-H2 can target ICP4, an essential viral protein. Interestingly, we found no evidence of hyperediting of its homolog, miR-H2, which is expressed by the closely related virus HSV-2. The discovery of post-translational modifications of viral miRNA in the latency phase suggests that these processes may also be important for other non-coding viral RNA in the latency phase, including the intron LAT, which in turn may be crucial for understanding the biology of this virus.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Virology
Numberingvol. 97, no. 10, pp. 1-21
p-ISSN0022-538X
e-ISSN1098-5514
DOIhttps://doi.org/10.1128/jvi.00730-23
URN:NBNurn:nbn:hr:184:705761
Publication2023-10-31
ProjectNumber: IP-2020-02-2287
Title (croatian): Uloga proteina ADAR kod infekcije herpes simpleks virusom 1
Title (english): Roles od ADAR proteins in herpes simples virus 1 infection
Acronym: eRNA-HSV-IJ
Leader: Igor Jurak
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://journals.asm.org/doi/10.1128/jvi.00730-23
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-11-13 12:31:27