prikaz prve stranice dokumenta Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia
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Scientific paper - Original scientific paper
Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia
Annals of Hepatology, 29 (2024), 1; 101156. https://doi.org/10.1016/j.aohep.2023.101156
Bubonja-Šonje, Marina; Peruč, Dolores; Abram, Maja; Mohar-Vitezić, Bojana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bubonja Šonje, M., Peruč, D., Abram, M. & Mohar Vitezić, B. (2024). Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia. Annals of Hepatology, 29. (1). doi: 10.1016/j.aohep.2023.101156

Bubonja Šonje, Marina, et al. "Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia." Annals of Hepatology, vol. 29, no. 1, 2024. https://doi.org/10.1016/j.aohep.2023.101156

Bubonja Šonje, Marina, Dolores Peruč, Maja Abram and Bojana Mohar Vitezić. "Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia." Annals of Hepatology 29, no. 1 (2024). https://doi.org/10.1016/j.aohep.2023.101156

Bubonja Šonje, M., et al. (2024) 'Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia', Annals of Hepatology, 29(1). doi: 10.1016/j.aohep.2023.101156

Bubonja Šonje M, Peruč D, Abram M, Mohar Vitezić B. Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia. Annals of Hepatology [Internet]. 2024 January [cited 2024 December 29];29(1). doi: 10.1016/j.aohep.2023.101156

M. Bubonja Šonje, D. Peruč, M. Abram and B. Mohar Vitezić, "Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia", Annals of Hepatology, vol. 29, no. 1, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:219252. [Accessed: 29 December 2024]

Metadata
Title (english)Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia
AuthorMarina Bubonja-Šonje
AuthorDolores Peruč
AuthorMaja Abram
AuthorBojana Mohar-Vitezić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Introduction and Objectives: Occult hepatitis B virus (HBV) infection (OBI) is characterised by low levels of hepatitis B virus (HBV) DNA in the blood/liver of patients with negative hepatitis B surface antigen (HBsAg). This study aimed to determine the OBI prevalence and virological characteristics (viral genotypes and HBsAg mutants) in patients with an "anti-HBc only" serological profile. Materials and Methods: A total of 24 900 serum samples were routinely screened for hepatitis B markers over a five-year period. All anti-HBc-positive/HBsAg-negative/anti-HBs-negative sera were selected and analysed for the presence of HBV DNA. Mutational analyses of the HBs gene and polymerase gene sequences were performed. Results: 1749 (7.02%) sera were anti-HBc positive, and 113 (0.45%) sera had an "anti-HBc only" serological profile (HBsAg/anti-HBs negative). HBV DNA was detected in 12/113 (10.61%) "anti-HBc only" positive sera, representing 0.048% of all routinely tested samples. Due to extremely low viremia, HBV genome was successfully sequenced in only two sera where subgenotype D3 was confirmed. Mutational analyses of the S gene revealed multiple missense mutations. In addition to the M133I, Y134F, and G145R mutations, already associated with diagnostic escape, we also found nine novel OBI-related S-gene mutations - S136Y, F158L, K160N, E164G, S167L, A168V, L175S, S210I and F212C. Conclusions: We detected multiple known and novel S gene mutations in 2/12 (16.6%) OBI cases, nevertheless, further studies are required to determine their role in the pathogenesis of OBI. Understanding the frequencies of clinically relevant HBV mutations may contribute to improvement of diagnostic protocols.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAnnals of Hepatology
Numberingvol. 29, no. 1, 101156
p-ISSN1665-2681
DOIhttps://doi.org/10.1016/j.aohep.2023.101156
URN:NBNurn:nbn:hr:184:219252
Publication2024-01
ProjectNumber: uniri-biomed-18-277
Title (croatian): Bakterijska patogeneza - od istraživanja do kliničke primjene
Title (english): Bacterial pathogenesis – from research to clinics
Leader: Maja Abram
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: uniri-biomed-18-215
Title (croatian): Proširenost i klinički značaj HBs antigenih mutanti virusa hepatitisa B
Title (english): Prevalence and clinical significance of hepatitis B surface antigen mutants
Leader: Marina Bubonja Šonje
Jurisdiction: Croatia
Funding stream: Nema
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1665268123002594
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-12-21 11:38:25