prikaz prve stranice dokumenta Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare
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Scientific paper - Original scientific paper
Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare
Processes, 12 (2024), 1; 111. https://doi.org/10.3390/pr12010111
Peruč, Dolores; Štifter-Vretenar, Sanja; Planinić, Ana; Gobin, Ivana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Peruč, D., Štifter Vretenar, S., Planinić, A. & Gobin, I. (2024). Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare. Processes, 12. (1). doi: 10.3390/pr12010111

Peruč, Dolores, et al. "Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare." Processes, vol. 12, no. 1, 2024. https://doi.org/10.3390/pr12010111

Peruč, Dolores, Sanja Štifter Vretenar, Ana Planinić and Ivana Gobin. "Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare." Processes 12, no. 1 (2024). https://doi.org/10.3390/pr12010111

Peruč, D., et al. (2024) 'Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare', Processes, 12(1). doi: 10.3390/pr12010111

Peruč D, Štifter Vretenar S, Planinić A, Gobin I. Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare. Processes [Internet]. 2024 January 02 [cited 2024 May 03];12(1). doi: 10.3390/pr12010111

D. Peruč, S. Štifter Vretenar, A. Planinić and I. Gobin, "Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare", Processes, vol. 12, no. 1, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:815932. [Accessed: 03 May 2024]

Metadata
Title (english)Combined Application of Juniperus communis Essential Oil and Amikacin, Clarithromycin and Rifampicin against Mycobacterium avium and Mycobacterium intracellulare
AuthorDolores Peruč
AuthorSanja Štifter-Vretenar
AuthorAna Planinić
AuthorIvana Gobin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
The group of nontuberculous mycobacteria (NTM) includes about 200 mycobacteria that are widespread in the natural environment as free-living saprophytic bacteria, commensals or symbionts. NTM, also referred to as atypical mycobacteria, are mostly apathogenic; nowadays, they are increasingly important environmental opportunistic pathogens. This study continues the work of previous studies which investigated the individual and synergistic effect of different essential oils (EOs) on NTM. The aim was to investigate the effect of the interaction of the common juniper (Juniperus communis) EO and the antimicrobials, amikacin, clarithromycin and rifampicin, against Mycobacterium avium and M. intracellulare using the checkerboard synergy method in an enriched Middlebrook 7H9 broth. Morphological changes of treated NTM cells were observed with a transmission electron microscope. The most synergistic combinations were found at subinhibitory concentrations of the common juniper EO and rifampicin against both tested NTM and this EO and clarithromycin against M. avium. A slightly smaller number of synergistic effects on both NTM were found using a combination of this EO and amikacin. Combinations of clarithromycin and the common juniper EO showed no synergism against M. intracellulare. The exposure of both NTM to synergistic combinations of this EO and antimicrobials caused significant morphological changes in mycobacterial cells. Synergism with the combined use of EOs and antimicrobials allows the use of low effective concentrations via the sustained antimicrobial effect of the tested substances, but with potentially reduced toxicity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProcesses
Numberingvol. 12, no. 1, 111
e-ISSN2227-9717
DOIhttps://doi.org/10.3390/pr12010111
URN:NBNurn:nbn:hr:184:815932
Publication2024-01-02
ProjectNumber: uniri-biomed-18-171
Title (croatian): Oportunistički patogeni vodoopskrbnog sustava: novi izazov u obradi voda
Title (english): Opportunistic Premise Plumbing Pathogens: New Challenge for Water Treatment
Leader: Ivana Gobin
Jurisdiction: Croatia
Funding stream: Nema
Document URLhttps://www.mdpi.com/2227-9717/12/1/111
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-03 12:47:20