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Scientific paper - Original scientific paper
Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic
Future Pharmacology, 4 (2024), 1; 115-138. https://doi.org/10.3390/futurepharmacol4010009
Filošević Vujnović, Ana; Stanković Matić, Ivana; Saftić Martinović, Lara; Dević Pavlić, Sanja

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Filošević Vujnović, A., Stanković Matić, I., Saftić Martinović, L. & Dević Pavlić, S. (2024). Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic. Future Pharmacology, 4. (1), 115-138. doi: 10.3390/futurepharmacol4010009

Filošević Vujnović, Ana, et al. "Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic." Future Pharmacology, vol. 4, no. 1, 2024, pp. 115-138. https://doi.org/10.3390/futurepharmacol4010009

Filošević Vujnović, Ana, Ivana Stanković Matić, Lara Saftić Martinović and Sanja Dević Pavlić. "Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic." Future Pharmacology 4, no. 1 (2024): 115-138. https://doi.org/10.3390/futurepharmacol4010009

Filošević Vujnović, A., et al. (2024) 'Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic', Future Pharmacology, 4(1), pp. 115-138. doi: 10.3390/futurepharmacol4010009

Filošević Vujnović A, Stanković Matić I, Saftić Martinović L, Dević Pavlić S. Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic. Future Pharmacology [Internet]. 2024 January 29 [cited 2024 December 23];4(1):115-138. doi: 10.3390/futurepharmacol4010009

A. Filošević Vujnović, I. Stanković Matić, L. Saftić Martinović and S. Dević Pavlić, "Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic", Future Pharmacology, vol. 4, no. 1, pp. 115-138, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:960552. [Accessed: 23 December 2024]

Metadata
Title (english)Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic
AuthorAna Filošević Vujnović
AuthorIvana Stanković Matić
AuthorLara Saftić Martinović
AuthorSanja Dević Pavlić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Cognitive Science (Natural, Technical, Biomedical and Healthcare, Social and Humanistic Sciences)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Addiction is a complex brain disease influenced by genetic, environmental, and neurological factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in different brain regions, with a focus on the neurons responsible for rewarding effects in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Known markers for psychostimulant-induced neuronal plasticity in combination with droplet-based high-throughput single-cell sequencing divided the heterogeneity of cell populations in NAc and VTA into clusters, where all cells of the same type do not respond equally to exposure to psychostimulants. To explain psychostimulant-induced neuronal plasticity as changes in the amplitude and phase shifts of gene expression, we focused on epigenetic mechanisms of DNA and chromatin modifications, as well as DNA accessibility. We also comment on epitranscriptomics as a novel approach in the study of messenger RNA posttranslational modification, which regulates translation and potentially localized transcription in synapses in order to address the molecular chains that connect addiction from changes in gene expression to synaptic and, finally, neuronal plasticity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFuture Pharmacology
Numberingvol. 4, no. 1, pp. 115-138
e-ISSN2673-9879
DOIhttps://doi.org/10.3390/futurepharmacol4010009
URN:NBNurn:nbn:hr:184:960552
Publication2024-01-29
Document URLhttps://www.mdpi.com/2673-9879/4/1/9
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-02-05 14:19:13