prikaz prve stranice dokumenta Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis
  Download
PDF 966.81 KB
Scientific paper - Original scientific paper
Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis
International Journal of Molecular Sciences, 25 (2024), 4; 2253. https://doi.org/10.3390/ijms25042253
Laškarin, Gordana; Babarović, Emina; Kifer, Nastasia; Bulimbašić, Stela; Šestan, Mario; Held, Martina; Frković, Marijan; Gagro, Alenka; Ćorić, Marijana; Jelušić, Marija

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Laškarin, G., Babarović, E., Kifer, N., Bulimbašić, S., Šestan, M., Held, M. ... Jelušić, M. (2024). Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis. International Journal of Molecular Sciences, 25. (4). doi: 10.3390/ijms25042253

Laškarin, Gordana, et al. "Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis." International Journal of Molecular Sciences, vol. 25, no. 4, 2024. https://doi.org/10.3390/ijms25042253

Laškarin, Gordana, Emina Babarović, Nastasia Kifer, Stela Bulimbašić, Mario Šestan, Martina Held, Marijan Frković, Alenka Gagro, Marijana Ćorić and Marija Jelušić. "Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis." International Journal of Molecular Sciences 25, no. 4 (2024). https://doi.org/10.3390/ijms25042253

Laškarin, G., et al. (2024) 'Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis', International Journal of Molecular Sciences, 25(4). doi: 10.3390/ijms25042253

Laškarin G, Babarović E, Kifer N, Bulimbašić S, Šestan M, Held M, and sur.. Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis. International Journal of Molecular Sciences [Internet]. 2024 February 13 [cited 2024 December 25];25(4). doi: 10.3390/ijms25042253

G. Laškarin, et al., "Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis", International Journal of Molecular Sciences, vol. 25, no. 4, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:856300. [Accessed: 25 December 2024]

Metadata
Title (english)Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis
AuthorGordana Laškarin
AuthorEmina Babarović
AuthorNastasia Kifer
AuthorStela Bulimbašić
AuthorMario Šestan
AuthorMartina Held
AuthorMarijan Frković
AuthorAlenka Gagro
AuthorMarijana Ćorić
AuthorMarija Jelušić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We investigated the polarisation of CD68+ macrophages and perforin and granulysin distributions in kidney lymphocyte subsets of children with IgA vasculitis nephritis (IgAVN). Pro-inflammatory macrophage (M)1 (CD68/iNOS) or regulatory M2 (CD68/arginase-1) polarisation; spatial arrangement of macrophages and lymphocytes; and perforin and granulysin distribution in CD3+ and CD56+ cells were visulaised using double-labelled immunofluorescence. In contrast to the tubules, iNOS+ cells were more abundant than the arginase-1+ cells in the glomeruli. CD68+ macrophage numbers fluctuated in the glomeruli and were mostly labelled with iNOS. CD68+/arginase-1+ cells are abundant in the tubules. CD56+ cells, enclosed by CD68+ cells, were more abundant in the glomeruli than in the tubuli, and co-expressed NKp44. The glomerular and interstitial/intratubular CD56+ cells express perforin and granulysin, respectively. The CD3+ cells did not express perforin, while a minority expressed granulysin. Innate immunity, represented by M1 macrophages and CD56+ cells rich in perforin and granulysin, plays a pivotal role in the acute phase of IgAVN.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 4, 2253
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25042253
URN:NBNurn:nbn:hr:184:856300
Publication2024-02-13
ProjectNumber: IP-2019-04-8822
Title (croatian): Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom
Title (english): Histological, Clinical, Laboratory and Genetic Predictors of Outcome in Patients with Henoch-Schönlein Purpura and Nephritis
Acronym: PURPURAPREDICTORS
Leader: Marija Jelušić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/1422-0067/25/4/2253
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-02-15 08:47:08