prikaz prve stranice dokumenta Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report
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Scientific paper - Case study
Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report
JBRA Assisted Reproduction, 27 (2023), 4; 747-751. https://doi.org/10.5935/1518-0557.20230027
Sušanj Šepić, Tina; Smiljan Severinski, Neda; Eminović, Senija; Radojčić Badovinac, Anđelka; Višnić, Alenka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Sušanj Šepić, T., Smiljan Severinski, N., Eminović, S., Radojčić Badovinac, A. & Višnić, A. (2023). Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report. JBRA Assisted Reproduction, 27. (4), 747-751. doi: 10.5935/1518-0557.20230027

Sušanj Šepić, Tina, et al. "Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report." JBRA Assisted Reproduction, vol. 27, no. 4, 2023, pp. 747-751. https://doi.org/10.5935/1518-0557.20230027

Sušanj Šepić, Tina, Neda Smiljan Severinski, Senija Eminović, Anđelka Radojčić Badovinac and Alenka Višnić. "Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report." JBRA Assisted Reproduction 27, no. 4 (2023): 747-751. https://doi.org/10.5935/1518-0557.20230027

Sušanj Šepić, T., et al. (2023) 'Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report', JBRA Assisted Reproduction, 27(4), pp. 747-751. doi: 10.5935/1518-0557.20230027

Sušanj Šepić T, Smiljan Severinski N, Eminović S, Radojčić Badovinac A, Višnić A. Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report. JBRA Assisted Reproduction [Internet]. 2023 [cited 2024 November 26];27(4):747-751. doi: 10.5935/1518-0557.20230027

T. Sušanj Šepić, N. Smiljan Severinski, S. Eminović, A. Radojčić Badovinac and A. Višnić, "Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report", JBRA Assisted Reproduction, vol. 27, no. 4, pp. 747-751, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:629794. [Accessed: 26 November 2024]

Metadata
Title (english)Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report
AuthorTina Sušanj Šepić
AuthorNeda Smiljan Severinski
AuthorSenija Eminović
AuthorAnđelka Radojčić Badovinac
AuthorAlenka Višnić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Case report: A 35-yr-old patient suffering from secondary amenorrhea for two years before she was diagnosed. Secondary amenorrhea occurred after the first normal vaginal delivery, and it was initially associated with breastfeeding and a formerly diagnosed thyroid disease. Transvaginal ultrasound confirmed a tumorous mass of the right ovary. Blood hormone tests detected high serum inhibin B and Anti-Müllerian hormone levels and high androgen level with no signs of virilization. Surgical treatment was indicated for a definitive diagnosis of suspected sex cord-stromal tumor. Right-sided laparoscopic salpingo-oophorectomy was performed, and the histopathological analysis confirmed the diagnosis of granulosa cell tumor adult type. The oncological team recommended adjuvant chemotherapy after the operation, but the patient did not give an informed consent. One month after surgical treatment, spontaneous menstrual bleeding occurred with normalization of sex hormone levels and the menstrual cycle. Nine months after surgical treatment, the patient was examined again due to secondary amenorrhea. Ultrasound confirmed a vital intrauterine pregnancy. The pregnancy course was normal, and the patient had a full-term spontaneous vaginal delivery of her second child. Conclusion: Restoration of fertility after a temporary loss due to hormone-secreting granulosa cell tumor is possible after sparing surgical treatment. The role of adjuvant chemotherapy is controversial, particularly in patients with stage I-II disease because of the rarity of this tumor and the absence of prospective randomized studies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJBRA Assisted Reproduction
Numberingvol. 27, no. 4, pp. 747-751
p-ISSN1518-0557
DOIhttps://doi.org/10.5935/1518-0557.20230027
URN:NBNurn:nbn:hr:184:629794
Publication2023
Document URLhttps://www.jbra.com.br/trab/pub/download_trabalho.php?fileSource=/var/www/vhosts/jbra.com.br/media/trab/arq_4896&fileName=2397%20-%20Complete.pdf&id_trabalho=1828
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-03-22 12:23:42