prikaz prve stranice dokumenta The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair
  Download
PDF 9.9 MB
Scientific paper - Original scientific paper
The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair
International Journal of Molecular Sciences, 25 (2024), 7; 3882. https://doi.org/10.3390/ijms25073882
Volarić, Darian; Žauhar, Gordana; Chen, Jie; Jerbić Radetić, Ana Terezija; Omrčen, Hrvoje; Raič, Antonio; Pirović, Roko; Cvijanović Peloza, Olga

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Volarić, D., Žauhar, G., Chen, J., Jerbić Radetić, A. T., Omrčen, H., Raič, A. ... Cvijanović Peloza, O. (2024). The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair. International Journal of Molecular Sciences, 25. (7). doi: 10.3390/ijms25073882

Volarić, Darian, et al. "The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair." International Journal of Molecular Sciences, vol. 25, no. 7, 2024. https://doi.org/10.3390/ijms25073882

Volarić, Darian, Gordana Žauhar, Jie Chen, Ana Terezija Jerbić Radetić, Hrvoje Omrčen, Antonio Raič, Roko Pirović and Olga Cvijanović Peloza. "The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair." International Journal of Molecular Sciences 25, no. 7 (2024). https://doi.org/10.3390/ijms25073882

Volarić, D., et al. (2024) 'The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair', International Journal of Molecular Sciences, 25(7). doi: 10.3390/ijms25073882

Volarić D, Žauhar G, Chen J, Jerbić Radetić AT, Omrčen H, Raič A, and sur.. The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair. International Journal of Molecular Sciences [Internet]. 2024 March 30 [cited 2024 May 09];25(7). doi: 10.3390/ijms25073882

D. Volarić, et al., "The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair", International Journal of Molecular Sciences, vol. 25, no. 7, March 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:313128. [Accessed: 09 May 2024]

Metadata
Title (english)The Effect of Low-Intensity Pulsed Ultrasound on Bone Regeneration and the Expression of Osterix and Cyclooxygenase-2 during Critical-Size Bone Defect Repair
AuthorDarian Volarić
AuthorGordana Žauhar
AuthorJie Chen
AuthorAna Terezija Jerbić Radetić
AuthorHrvoje Omrčen
AuthorAntonio Raič
AuthorRoko Pirović
AuthorOlga Cvijanović Peloza
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound that utilizes low-intensity pulsed waves. Its effect on bones that heal by intramembranous ossification has not been sufficiently investigated. In this study, we examined LIPUS and the autologous bone, to determine their effect on the healing of the critical-size bone defect (CSBD) of the rat calvaria. The bone samples underwent histological, histomorphometric and immunohistochemical analyses. Both LIPUS and autologous bone promoted osteogenesis, leading to almost complete closure of the bone defect. On day 30, the bone volume was the highest in the autologous bone group (20.35%), followed by the LIPUS group (19.12%), and the lowest value was in the control group (5.11%). The autologous bone group exhibited the highest intensities of COX-2 (167.7 ± 1.1) and Osx (177.1 ± 0.9) expression on day 30. In the LIPUS group, the highest intensity of COX-2 expression was found on day 7 (169.7 ±1.6) and day 15 (92.7 ± 2.2), while the highest Osx expression was on day 7 (131.9 ± 0.9). In conclusion, this study suggests that LIPUS could represent a viable alternative to autologous bone grafts in repairing bone defects that are ossified by intramembranous ossification.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 7, 3882
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25073882
URN:NBNurn:nbn:hr:184:313128
Publication2024-03-30
ProjectNumber: uniri-biomed-18-280
Title (croatian): Reparacija i imunosni odgovor koštanog tkiva nakon primjene novog biomaterijala te imunosni odgovor mekog tkiva na Jason membranu u štakoru
Title (english): Reparation and immune response of bone tissue after applying new biomaterial and immune response of soft tissue on Jason® membrane in rat
Leader: Olga Peloza
Jurisdiction: Croatia
Funding stream: Nema
Document URLhttps://www.mdpi.com/1422-0067/25/7/3882
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-04-02 10:20:14