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Professional paper - Review paper
Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece
Medicina Fluminensis : Medicina Fluminensis, 44 (2008), 1; 16-21. urn:nbn:hr:184:877593
Roganović, Jelena

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Roganović, J. (2008). Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece. Medicina Fluminensis : Medicina Fluminensis, 44. (1), 16-21. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:877593

Roganović, Jelena. "Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece." Medicina Fluminensis : Medicina Fluminensis, vol. 44, no. 1, 2008, pp. 16-21. https://urn.nsk.hr/urn:nbn:hr:184:877593

Roganović, Jelena. "Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece." Medicina Fluminensis : Medicina Fluminensis 44, no. 1 (2008): 16-21. https://urn.nsk.hr/urn:nbn:hr:184:877593

Roganović, J. (2008) 'Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece', Medicina Fluminensis : Medicina Fluminensis, 44(1), pp. 16-21. Available at: https://urn.nsk.hr/urn:nbn:hr:184:877593 (Accessed 25 December 2024)

Roganović J. Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2008 June 01 [cited 2024 December 25];44(1):16-21. Available at: https://urn.nsk.hr/urn:nbn:hr:184:877593

J. Roganović, "Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece", Medicina Fluminensis : Medicina Fluminensis, vol. 44, no. 1, pp. 16-21, June 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:877593. [Accessed: 25 December 2024]

Metadata
Title (croatian)Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece
Title (english)Pharmacogenomics in the treatment of acute lymphoblastic leukemia in children
AuthorJelena Roganović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (croatian)
SAŽETAK. Posljednjih desetljeća postignut je izvanredan napredak u liječenju akutnih limfatičnih leukemija u djece. Farmakogenomika akutnih leukemija izučava genetičku kontrolu mehanizama koji utječu na antileukemijski učinak lijekova i razvoja rezistencije na ove lijekove. Cilj farmakogenomike pedijatrijskih akutnih limfatičnih leukemija je identifikacija onih dijelova genoma koji su odgovorni za poželjne i nepoželjne učinke pojedinih citotoksičnih lijekova, u ovisnosti o individualnoj sposobnosti oboljelog djeteta da lijek iskoristi, metabolizira i eliminira. Stoga farmakogenomika pruža opravdanu nadu u mogućnost optimalizacije i individualizacije terapije, te daljnjeg poboljšanja rezultata liječenja djece s akutnom limfatičnom leukemijom.
Abstract (english)
ABSTRACT. Over the past decades, the treatment of acute lymphoblastic leukemia in children has made remarkable progress. Pharmacogenomics of acute leukemias elucidates mechanisms of genetic control of antileukemic effects of chemotherapy and development of drug resistance. The aim of pharmacogenomic studies, related to the treatment of pediatric acute lymphoblastic leukemias, is to identify genes responsible for drug efficacy and toxicity, matched with the genetic makeup of every individual child. Pharmacogenomics offers the reasonable promise of therapeutic optimization and individualization, and further improvement of treatment outcome in childhood lymphoblastic leukemia.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 44, no. 1, pp. 16-21
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:877593
Publication2008-06-01
Document URLhttp://hrcak.srce.hr/25944
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-28 08:32:00