Title Minimalno invazivne metode u liječenju karcinoma bubrega
Title (english) Minimally invasive methods in the treatment of kidney cancer
Author Matea Novokmet
Mentor Dean Markić (mentor)
Committee member Stanislav Sotošek (predsjednik povjerenstva)
Committee member Romano Oguić (član povjerenstva)
Committee member Josip Španjol (član povjerenstva)
Granter University of Rijeka Faculty of Medicine Rijeka
Defense date and country 2024-07-12, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Urology
Abstract Bubrezi su parni organi koji se nalaze retroperitonealno i dio su mokraćnog sustava. Glavna zadaća bubrega je filtriranje krv i bitni su za normalno funkcioniranje organizma. Tumori bubrega su česti tumori i najčešće se nađu slučajno na slikovnim pretragama. Najzastupljeniji maligni tumor bubrega je karcinom bubrežnih stanica. Liječenje tumora bubrega je kirurški, medikamentozno, zračenjem ili minimalno invazivnim metodama. Radikalna nefrektomija je „zlatni standard“ u liječenju i ona se danas može izvesti laparoskopijom koja je minimalno invazivna. Laparoskopski pristup ima prednost nad otvorenim zbog smanjene boli na mjestu incizije i posljedično manje uporabe analgetika, kraći je postoperativni oporavak, bolja procjena izgubljene krv, manji rez i očuvanje nefrona. Minimalno invazivne metode liječenja karcinoma bubrega su: perkutana radiofrekventna ablacija, krioablacija, ablacija mikrovalovima, laserska ablacija i ablacija ultrazvukom. Ove metode se sve više koriste jer imaju smanjen morbiditet, kraće vrijeme hospitalizacije i mogućnost liječenja bolesnika koji imaju visok operacijski rizik. Perkutana radiofrekventna ablacija je najčešće korištena ablacijska metoda jer je najviše istražena. RFA dovodi do potpune ablacije tumora manjih od 3cm. Prednosti ove metode su minimalna invazivnost, smanjena bol i kraće vrijeme boravka u bolnici. Princip rada radiofrekventne ablacije se temelji na transformaciji električne energije u toplinu. Krioablacija je postupak u kojem se koristi hladna tekućina ili instrument koji se naziva kriosonda na temperaturi manjoj od 25° za zamrzavanje i uništavanje tumorskog tkiva. Mikrovalna ablacija je tehnika koja koristi toplinu iz mikrovalne energije spektra elektromagnetskog zračenja između 300 MHz i 300 Ghz, za uništenje stanica tumora.
Abstract (english) Kidneys are paired organs located retroperitoneally and are part of the urinary system. The main task of the kidneys is to filter the blood and they are essential for the normal functioning of the body. Kidney tumors are common tumors and are most often found accidentally on imaging tests. The most common malignant kidney tumor is renal cell carcinoma. Treatment of kidney tumors is surgical, medicinal, radiation or minimally invasive methods. Radical nephrectomy is the "gold standard" in treatment and today it can be performed by laparoscopy, which is minimally invasive. The laparoscopic approach has an advantage over the open one due to reduced pain at the incision site and consequently less use of analgesics, shorter postoperative recovery, better assessment of lost blood, smaller incision and nephron preservation. Minimally invasive methods of kidney cancer treatment are: percutaneous radiofrequency ablation, cryoablation, microwave ablation, laser ablation and ultrasound ablation. These methods are used more and more because they have reduced morbidity, shorter hospitalization time and the possibility of treating patients who have a high surgical risk. Percutaneous radiofrequency ablation is the most commonly used ablation method because it is the most researched. RFA leads to complete ablation of tumors smaller than 3 cm. The advantages of this method are minimal invasiveness, reduced pain and shorter hospital stay. The principle of operation of radiofrequency ablation is based on the transformation of electrical energy into heat. Cryoablation is a procedure in which a cold liquid or an instrument called a cryoprobe is used at a temperature of less than 25° to freeze and destroy tumor tissue. Microwave ablation is a technique that uses heat from microwave energy of the spectrum of electromagnetic radiation between 300 MHz and 300 Ghz, to destroy tumor cells.
Keywords
karcinom bubrega
radiofrekventna ablacija
krioablacija
mikrovalna ablacija
radikalna nefrektomija
parcijalna nefrektomija
laparoskopija
Keywords (english)
kidney cancer
radiofrequency ablation
cryoablation
microwave ablation
radical nephrectomy
partial nephrectomy
laparoscopy
Language croatian
URN:NBN urn:nbn:hr:184:904369
Study programme Title: Medicine Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resource Text
File origin Born digital
Access conditions Open access
Terms of use
Created on 2024-06-24 16:32:24