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master's thesis
FRONTOTEMPORALNA DEMENCIJA
diplomski rad
Rijeka: University of Rijeka, Faculty of Medicine, 2024. urn:nbn:hr:184:059923
Magaš, Luka
University of Rijeka
Faculty of Medicine
Department of Neurology

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Magaš, L. (2024). FRONTOTEMPORALNA DEMENCIJA : diplomski rad (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:059923

Magaš, Luka. "FRONTOTEMPORALNA DEMENCIJA : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:184:059923

Magaš, Luka. "FRONTOTEMPORALNA DEMENCIJA : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:184:059923

Magaš, L. (2024). 'FRONTOTEMPORALNA DEMENCIJA : diplomski rad', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:059923

Magaš L. FRONTOTEMPORALNA DEMENCIJA : diplomski rad [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2024 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:184:059923

L. Magaš, "FRONTOTEMPORALNA DEMENCIJA : diplomski rad", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:184:059923

Metadata
TitleFRONTOTEMPORALNA DEMENCIJA : diplomski rad
Title (english)FRONTOTEMPORAL DEMENTIA : graduate thesis
AuthorLuka Magaš
MentorVladimira Vuletić (mentor)
Committee memberOlivio Perković (predsjednik povjerenstva)
Committee memberSiniša Dunatov (član povjerenstva)
Committee memberDavid Bonifačić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Rijeka
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Frontotemporalna demencija (FTD) je neurodegenerativna bolest i treća po učestalosti demencija u svijetu. Prvi ju je opisao češki neurolog Albert Pick, 1892.godine. Postoje tri varijante FTD-a: bihevioralna varijanta FTD-a (bvFTD), semantička varijanta primarne progresivne afazije (svPPA) i nefluentna/agramatička varijanta PPA (nfvPPA). Glavni mehanizam nastanka FTD-a je frontotemporalna lobarna degeneracija (FTLD). To je neuropatološki proces u kojem dolazi do atrofije frontalnog i temporalnog režnja mozga. Pretpostavlja se da je 40% slučajeva FTD-a uzrokovano genskom mutacijom. Simptomi se obično ranije prezentiraju, nego kod ostalih oblika demencija. Bihevioralna varijanta može imati slične simptome kao i razna psihijatrijska oboljenja. To je i razlog zbog kojega pacijenti često odlaze na prvi pregled kod psihijatra. Međutim, postoje dijagnostički kriteriji iz 2011. godine, koji mogu pomoći pri dijagnosticiranju bvFTD-a. Primarna progresivna afazija se sastoji od dva oblika: svPPA i nfvPPA. Pacijenti sa semantičkom varijantom imaju poremećeno razumijevanje pojedinih riječi s očuvanom gramatikom, dok pacijenti s nefluentnom/agramatičkom varijantom, imaju poremećeno razumijevanje složenih riječi i otežan govor radi nerazumijevanja gramatike. Obije varijante PPA imaju zasebne dijagnostičke kriterije po Mesulamu. Trenutno FDA i EMA ne propisuju niti jedno specifično liječenje za FTD. Jedina mogućnost liječenja kod ovih pacijenata je farmakološka ili nefarmakološka simptomatska terapija. Provode se istraživanja, čija je zadaća pronaći specifične lijekove koji se mogu koristiti u obliku genske terapije, ali su ona još uvijek u ranim fazama pretkliničkih i kliničkih istraživanja.
Abstract (english)
Frontotemporal dementia (FTD) is a neurodegenerative disease and the third most common form of dementia in the world. It was first described by the Czech neurologist Albert Pick in 1892. There are three variants of FTD: behavioral variant of FTD (bvFTD), semantic variant of primary progressive aphasia (svPPA), and non-fluent/agrammatic variant of PPA (nfvPPA). The main mechanism of FTD is frontotemporal lobar degeneration (FTLD). It is a neuropathological process in which the frontal and temporal lobes of the brain atrophy. It is thought that 40% of FTD cases are caused by a gene mutation. Symptom onset is usually earlier than in other forms of dementia. Behavioural variant can have similar symptoms as various psychiatric disorders. This is also the reason why these patients often go to a psychiatrist for their first examination. However, there are diagnostic criteria from 2011 that can help diagnose bvFTD. Primary progressive aphasia consists of two forms: svPPA and nfvPPA. Patients with the semantic variant have impaired understanding of individual words with preserved grammar, while patients with the non-fluent/agrammatic variant have impaired understanding of complex words and difficult speech due to lack of understanding of grammar. Both variants of PPA have separate diagnostic criteria based on Mesulam. Currently, the FDA and EMA do not prescribe any specific treatment for FTD. The only treatment option for these patients is pharmacological or non-pharmacological symptomatic therapy. Research is being conducted to find specific drugs that can be used in the form of gene therapy, but they are still in the early stages of preclinical and clinical research.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:059923
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-27 14:28:23