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master's thesis
Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca
Rijeka: University of Rijeka, Faculty of Medicine, 2024. urn:nbn:hr:184:171349
Bogdanović, Katarina
University of Rijeka
Faculty of Medicine

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bogdanović, K. (2024). Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:171349

Bogdanović, Katarina. "Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca." Master's thesis, University of Rijeka, Faculty of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:184:171349

Bogdanović, Katarina. "Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca." Master's thesis, University of Rijeka, Faculty of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:184:171349

Bogdanović, K. (2024). 'Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:184:171349

Bogdanović K. Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2024 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:184:171349

K. Bogdanović, "Novi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:184:171349

Metadata
TitleNovi kardiovaskularni biljezi u bolesnika hospitaliziranih zbog zatajivanja srca
Title (english)New Cardiovascular Biomarkers in Hospitalized Heart Failure Patients
AuthorKatarina Bogdanović
MentorTeodora Zaninović Jurjević (mentor)
Committee memberVjekoslav Tomulić (predsjednik povjerenstva)
Committee memberLidija Orlić (član povjerenstva)
Committee memberTomislav Jakljević (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
Rijeka
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Zatajivanje srca je povezano je s velikim financijskim opterećenjem za zdravstveni sustav. Predlaže se uključivanje novijih biljega uz kliničku procjenu za dijagnozu i prognozu akutnog ZS kako bi se smanjile stope hospitalizacije i u konačnici smanjio morbiditet i mortalitet. Interes za uporabu biljega u ZS raste velikom brzinom. Natriuretski peptidi su i dalje primarni biljezi koji pomažu u dijagnozi akutnog dekompenziranog ZS uz srčani troponin. Također, sST2 i Gal-3 su ušli u smjernice ACC/AHA. Istovremeno GDF 15 pokazuje ohrabrujuće rezultate u prognozi bolesnika sa ZS. Navedenim biljezima često nedostaje specifičnosti, primjerice kod multisistemskih poremećaja kao što su akutno oštećenje bubrega i nekontrolirana hipertenzija. Rezultati vrijednosti biljega mogu biti „pogrešni“, ipak u odgovarajućem kliničkom kontekstu njihova primjena se i dalje može razmotriti. Područje biljega u ZS je vrlo dinamično sa velikim brojem istraživanja novih biljega. Potrebne su nove randomizirane kliničke studije za potvrdu upotrebe novih biljega u širokoj lepezi raznih kliničkih slika sindroma ZS.
Abstract (english)
Heart failure is associated with a significant financial burden on the healthcare system. It is proposed to include newer biomarkers along with clinical assessment for the diagnosis and prognosis of acute heart failure (HF) to reduce hospitalization rates and ultimately decrease morbidity and mortality. Interest in the use of biomarkers in HF is rapidly growing. Natriuretic peptides remain the primary biomarkers aiding in the diagnosis of acute decompensated HF alongside cardiac troponin. Additionally, sST2 and Gal-3 have been incorporated into the ACC/AHA guidelines. Concurrently, GDF-15 shows promising results in the prognosis of HF patients. These biomarkers often lack specificity, for instance, in multisystem disorders such as acute kidney injury and uncontrolled hypertension. The biomarker values may be "misleading," but their application can still be considered in the appropriate clinical context. The field of biomarkers in HF is very dynamic, with numerous studies on new biomarkers. New randomized clinical trials are needed to confirm the use of new biomarkers across a wide range of clinical presentations of the HF syndrome.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:171349
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-07 18:40:07