prikaz prve stranice dokumenta Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
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Scientific paper - Original scientific paper
Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
Environmental Research, 260 (2024); 119583. https://doi.org/10.1016/j.envres.2024.119583
Palir, Neža; Stajnko, Anja; Mazej, Darja; France Štiglic, Alenka; Rosolen, Valentina; Mariuz, Marika; Ronfani, Luca; Snoj Tratnik, Janja; Runkel, Agneta Annika; Tursunova, Veronika; Marc, Janja; Prpić, Igor; Špirić, Zdravko; Barbone, Fabio; Horvat, Milena; Falnoga, Ingrid More authors...

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Cite this document

Palir, N., Stajnko, A., Mazej, D., France Štiglic, A., Rosolen, V., Mariuz, M. ... Falnoga, I. (2024). Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels. Environmental Research, 260.. doi: 10.1016/j.envres.2024.119583

Palir, Neža, et al. "Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels." Environmental Research, vol. 260, 2024. https://doi.org/10.1016/j.envres.2024.119583

Palir, Neža, Anja Stajnko, Darja Mazej, Alenka France Štiglic, Valentina Rosolen, Marika Mariuz, Luca Ronfani, et al. "Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels." Environmental Research 260 (2024). https://doi.org/10.1016/j.envres.2024.119583

Palir, N., et al. (2024) 'Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels', Environmental Research, 260. doi: 10.1016/j.envres.2024.119583

Palir N, Stajnko A, Mazej D, France Štiglic A, Rosolen V, Mariuz M, and sur.. Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels. Environmental Research [Internet]. 2024 November [cited 2024 December 24];260. doi: 10.1016/j.envres.2024.119583

N. Palir, et al., "Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels", Environmental Research, vol. 260, November 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:711087. [Accessed: 24 December 2024]

Metadata
Title (english)Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
AuthorNeža Palir
AuthorAnja Stajnko
AuthorDarja Mazej
AuthorAlenka France Štiglic
AuthorValentina Rosolen
AuthorMarika Mariuz
AuthorLuca Ronfani
AuthorJanja Snoj Tratnik
AuthorAgneta Annika Runkel
AuthorVeronika Tursunova
AuthorJanja Marc
AuthorIgor Prpić
AuthorZdravko Špirić
AuthorFabio Barbone
AuthorMilena Horvat
AuthorIngrid Falnoga
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ε2, ε3, ε4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58–87.6) and 9.31 (1.82–47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEnvironmental Research
Numberingvol. 260, 119583
p-ISSN0013-9351
DOIhttps://doi.org/10.1016/j.envres.2024.119583
URN:NBNurn:nbn:hr:184:711087
Publication2024-11
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0013935124014889
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2024-08-14 10:17:16